Anghel Narcis, Melinte Violeta, Spiridon Iuliana, Pertea Mihaela
Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Department of Plastic Surgery and Reconstructive Microsurgery, Grigore T. Popa University of Medicine and Pharmacy of Iasi, St. Spiridon Emergency County Hospital, 700115 Iasi, Romania.
Pharmaceutics. 2022 Oct 22;14(11):2260. doi: 10.3390/pharmaceutics14112260.
β-Cyclodextrin was attached to lignin/lignin crosslinked by epichlorohydrin and served as a drug delivery matrix. Ketoconazole and piroxicam were added into the polymeric matrix as antifungal and anti-inflammatory agents, respectively. The percentage of drug retained ranged from 48.4% to 58.4% for ketoconazole and piroxicam, respectively. It was found that their tensile strengths increased with decreasing particle size, ranging between 59% and 71% for lignin crosslinked with β-cyclodextrin base matrix (LCD). Depending on the polymeric matrix, the drug release kinetics fit well in the Korsmeyer-Peppas model, with or without Fickian diffusion. From the materials based on the mixture of epoxidized lignin and β-cyclodextrin, the medicines were released more slowly (the release rate constant presents lower values ranging between 1.117 and 1.783), as compared with those comprising LCD (2.210-4.824). The materials were also demonstrated to have antimicrobial activity. The antioxidant activity of LCD loaded with piroxicam was found to be 23.9% greater than that of the base matrix (LCD). These findings could be useful towards β-cyclodextrin attached to lignin formulation development of drug carriers with antioxidant activity.
β-环糊精连接到通过环氧氯丙烷交联的木质素/木质素上，并用作药物递送基质。酮康唑和吡罗昔康分别作为抗真菌剂和抗炎剂添加到聚合物基质中。酮康唑和吡罗昔康的药物保留率分别为48.4%至58.4%。研究发现，它们的拉伸强度随着粒径的减小而增加，与β-环糊精基基质（LCD）交联的木质素的拉伸强度在59%至71%之间。根据聚合物基质的不同，药物释放动力学在有或没有菲克扩散的情况下都很好地符合Korsmeyer-Peppas模型。与包含LCD的材料（2.210 - 4.824）相比，由环氧化木质素和β-环糊精混合物制成的材料中药物释放得更慢（释放速率常数呈现较低值，范围在1.117至1.783之间）。这些材料还被证明具有抗菌活性。负载吡罗昔康的LCD的抗氧化活性比基础基质（LCD）高23.9%。这些发现可能有助于开发具有抗氧化活性的连接到木质素的β-环糊精药物载体配方。
