Department of Civil & Environmental Engineering, University of Pittsburgh, Pittsburgh, PA, USA; National Research Center for Environmental Analysis and Measurement, Beijing, Beijing, China.
National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
J Hazard Mater. 2023 Feb 5;443(Pt B):130235. doi: 10.1016/j.jhazmat.2022.130235. Epub 2022 Oct 28.
Chlorinated paraffins (CPs), particularly short-chain CPs (SCCPs), have been reported in human blood with high detection frequency and often high variation among individuals. However, factors associated with and their contributions to inter-individual variability in SCCP concentrations in human blood have not been assessed. In this study, we first measured SCCP concentrations in 57 human blood samples collected from individuals living in the same vicinity in China. We then used the PROduction-To-Exposure model to investigate the impacts of variations in sociodemographic data, biotransformation rates, dietary patterns, and indoor contamination on inter-individual variability in SCCP concentrations in human blood. Measured ∑SCCP concentrations varied by a factor of 10 among individuals with values ranging from 122 to 1230 ng/g, wet weight. Model results show that age, sex, body weight, and dietary composition played a minor role in causing variability in ∑SCCP concentrations in human blood given that modeled ∑SCCP concentrations ranged over a factor of 2 - 3 correlated to the variations of these factors. In contrast, variations in the modeled ΣSCCP concentrations increased to factors of 6 and 8 when variability in biotransformation rates and indoor contamination were considered, respectively, indicating these two factors could be the most influential on inter-individual variability in SCCP concentrations in human blood.
短链氯化石蜡（SCCPs）在人体血液中被广泛检出，且个体间浓度差异较大。然而，目前仍不清楚导致 SCCP 个体间浓度差异的相关因素及其作用。本研究首次测量了来自中国同一地区的 57 个人体血液样本中的 SCCP 浓度，然后利用 PROduction-To-Exposure 模型，研究了社会人口统计学数据、生物转化率、饮食模式和室内污染等因素的变化对人体血液中 SCCP 浓度个体间差异的影响。在所研究的个体中，ΣSCCP 浓度的差异高达 10 倍，范围为 122-1230ng/g（湿重）。模型结果表明，年龄、性别、体重和饮食组成在导致人体血液中 ΣSCCP 浓度个体间差异方面作用较小，因为模型预测的 ΣSCCP 浓度与这些因素的变化范围相差 2-3 倍。相比之下，当考虑生物转化率和室内污染的变异性时，模型预测的 ΣSCCP 浓度的变异性分别增加到 6 倍和 8 倍，表明这两个因素可能是影响人体血液中 SCCP 浓度个体间差异的最主要因素。
