Parizkova Denisa, Sykorova Aneta, Tomasko Jakub, Parizek Ondrej, Pulkrabova Jana
Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technicka 3, 166 28 Prague, Czech Republic.
J Xenobiot. 2024 Dec 18;14(4):2003-2014. doi: 10.3390/jox14040107.
Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) are environmental contaminants known for their persistence and bioaccumulation in fatty tissues. SCCPs are considered potential carcinogens and endocrine disruptors, with similar effects expected for MCCPs. This study investigated the body burden of SCCPs and MCCPs in residents of two regions of the Czech Republic with different levels of industrial pollution. Blood serum samples from 62 individuals in Ceske Budejovice (control area) and Ostrava (industrial area) were analysed. The results showed higher concentrations of SCCPs (<120-650 ng/g lipid weight (lw)) and MCCPs (<240-1530 ng/g lw) in Ostrava compared to Ceske Budejovice (SCCPs: <120-210 ng/g lw, MCCPs: <240-340 ng/g lw). The statistical analysis revealed no significant correlations between chemical concentrations and demographic variables such as age, BMI, or gender. The findings are consistent with European and Australian studies but significantly lower than levels reported in China. This is the first comprehensive survey of SCCPs and MCCPs in human blood serum in the Czech Republic and the second study in Europe. The data collected in this study are essential for assessing SCCPs and MCCPs. They will contribute to a better understanding the potential health risks associated with exposure to these chemicals.
短链和中链氯化石蜡（SCCPs和MCCPs）是环境污染物，因其在脂肪组织中的持久性和生物累积性而闻名。SCCPs被认为是潜在的致癌物和内分泌干扰物，预计MCCPs也有类似影响。本研究调查了捷克共和国两个工业污染程度不同地区居民体内SCCPs和MCCPs的负荷情况。分析了来自捷克布杰约维采（对照区）和俄斯特拉发（工业区）的62个人的血清样本。结果显示，与捷克布杰约维采（SCCPs：<120 - 210 ng/g脂质重量（lw），MCCPs：<240 - 340 ng/g lw）相比，俄斯特拉发的SCCPs（<120 - 650 ng/g lw）和MCCPs（<240 - 1530 ng/g lw）浓度更高。统计分析表明，化学物质浓度与年龄、体重指数或性别等人口统计学变量之间无显著相关性。这些发现与欧洲和澳大利亚的研究结果一致，但显著低于中国报告的水平。这是捷克共和国首次对人体血清中的SCCPs和MCCPs进行的全面调查，也是欧洲的第二项研究。本研究收集的数据对于评估SCCPs和MCCPs至关重要。它们将有助于更好地了解接触这些化学物质所带来的潜在健康风险。
