Department of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Cereb Blood Flow Metab. 2023 Mar;43(3):341-356. doi: 10.1177/0271678X221138412. Epub 2022 Nov 11.
Macrophage migration inhibitory factor (MIF) is involved in various immune-mediated pathologies and regulates both innate and adaptive immune reactions, thus being related to several acute and chronic inflammatory diseases such as rheumatoid arthritis, septic shock, and atherosclerosis. Its role in acute and chronic brain pathologies, such as stroke and neurodegenerative diseases, has attracted increasing attention in recent years. In response to stimuli like hypoxia, inflammation or infection, different cell types can rapidly release MIF, including immune cells, endothelial cells, and neuron cells. Notably, clinical data from past decades also suggested a possible link between serum MIF levels and the severity of stroke and the evolving of neurodegenerative diseases. In this review, we summarize the major and recent findings focusing on the mechanisms of MIF modulating functions in brain injury and neurodegenerative diseases, which may provide important therapeutic targets meriting further investigation.
巨噬细胞移动抑制因子（MIF）参与多种免疫介导的病理过程，并调节固有和适应性免疫反应，因此与类风湿性关节炎、败血症性休克和动脉粥样硬化等多种急性和慢性炎症性疾病有关。近年来，其在急性和慢性脑病理中的作用，如中风和神经退行性疾病，引起了越来越多的关注。在缺氧、炎症或感染等刺激下，不同的细胞类型可以迅速释放 MIF，包括免疫细胞、内皮细胞和神经元细胞。值得注意的是，过去几十年的临床数据也表明，血清 MIF 水平与中风的严重程度和神经退行性疾病的发展之间可能存在关联。在这篇综述中，我们总结了主要和最新的发现，重点介绍了 MIF 调节脑损伤和神经退行性疾病中功能的机制，这可能为进一步研究提供重要的治疗靶点。
