Darwish Mirhane Mostafa, Elneklawi Mona S, Mohamad Ebtesam A
Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Biomedical Equipment Department, Faculty of Applied Medical Sciences, October 6 University, 6th of October City, Giza, Egypt.
J Biomater Sci Polym Ed. 2023 Apr;34(6):810-827. doi: 10.1080/09205063.2022.2145869. Epub 2022 Nov 15.
The goal of this work is to encapsulate essential oil in biopolymer matrices, to optimize the biological effects and the antibacterial properties of this oil. In this study, Eucalyptus extract was encapsulated in Aloe Vera coated Dextran Sulfate/Chitosan nanoparticles to form a hydrogel with potent properties. In this study, Eucalyptus extract was loaded on to Aloe Vera coated Dextran Sulphate/Chitosan nanoparticles to obtain a nano-hydrogel with potent properties. The characterization of nanoparticles was evaluated using transmission and scanning electron microscopes, dynamic light scattering, Fourier transform infrared spectroscopy, differential scanning calorimetry and antibacterial activity. The release profile from the prepared nanoparticles was studied at a pH of 7.4. The results showed that this nano-carrier controls Eucalyptus release. Aloe Vera coated Dextran Sulfate/Chitosan nanoparticles encapsulated with inhibited the bacteria by 47.27%. These investigations concluded that loaded Aloe Vera coated Dextran Sulfate/Chitosan hydrogel could be used as a powerful dressing material to accelerate wound healing.
这项工作的目标是将精油包裹在生物聚合物基质中，以优化该精油的生物学效应和抗菌性能。在本研究中，将桉叶提取物包裹在芦荟涂层的硫酸葡聚糖/壳聚糖纳米颗粒中，以形成具有强效性能的水凝胶。在本研究中，将桉叶提取物负载到芦荟涂层的硫酸葡聚糖/壳聚糖纳米颗粒上，以获得具有强效性能的纳米水凝胶。使用透射和扫描电子显微镜、动态光散射、傅里叶变换红外光谱、差示扫描量热法和抗菌活性对纳米颗粒进行表征。在pH值为7.4的条件下研究了所制备纳米颗粒的释放曲线。结果表明，这种纳米载体可控制桉叶提取物的释放。包裹有桉叶提取物的芦荟涂层硫酸葡聚糖/壳聚糖纳米颗粒对细菌的抑制率为47.27%。这些研究得出结论，负载有桉叶提取物的芦荟涂层硫酸葡聚糖/壳聚糖水凝胶可作为一种强大的敷料材料来加速伤口愈合。
