Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China.
Front Public Health. 2022 Oct 31;10:1036264. doi: 10.3389/fpubh.2022.1036264. eCollection 2022.
Many studies have focused on the distribution and specific clinical symptoms caused by . Still, relatively few studies have focused on the associations between genotypes and cervical intraepithelial lesions.
This study was conducted to determine the distribution of genotypes and its associations with cervical intraepithelial lesions among women of reproductive age. The presence of other STIs coinfection was also evaluated.
375 positive cervical swabs collected from women of reproductive age were analyzed though molecular assay. Multivariate logistic regression analyses (covariates include contraception, gravidity (≥1), abnormal vaginal discharge, adverse pregnancy outcomes, reproductive tract symptoms and abnormal cervical cytology) were performed to evaluate the associations between genotypes and cervical intraepithelial lesions and genital clinical symptoms.
Among 375 positive cervical swabs, the prevalence of coinfection with , and HPV were 0.8%, 2.7%, 2.4%, 10.1% and 15.5%, respectively. 306 were genotyped successfully, and nine genotypes were identified. The most common genovar was E (25.16%, 77/306), followed by J (22.55%, 69/306), F (17%, 52/306), D (14.4%, 44/306), K (7.2%, 22/306), G (6.9%, 21/306), H (5.2%, 16/306), B (1.0%, 3/306), Ia (0.7%, 2/306). Genotype H was associated with abnormal cervical cytology [ = 0.006, aOR = 8.16 (1.86-36.6)]. However, this study observed no association between genotypes and any genital clinical symptoms.
genotype H may be a high risk factor for cervical intraepithelial lesions, which is useful for treatment and management measures for patients with cervical intraepithelial lesions.
许多研究都集中在 的分布和其引起的特定临床症状上。然而，相对较少的研究集中在 基因型与宫颈上皮内病变之间的关联上。
本研究旨在确定生殖年龄段妇女中 基因型的分布及其与宫颈上皮内病变的关系，并评估其他性传播感染（STI）合并感染的情况。
通过分子检测分析了 375 例来自生殖年龄段妇女的阳性宫颈拭子。采用多变量逻辑回归分析（协变量包括避孕、孕次（≥1）、异常阴道分泌物、不良妊娠结局、生殖道症状和异常宫颈细胞学），评估 基因型与宫颈上皮内病变和生殖器临床症状之间的关系。
在 375 例阳性宫颈拭子中，合并感染 、HPV 的比例分别为 0.8%、2.7%、2.4%、10.1%和 15.5%。成功对 306 例进行了基因分型，鉴定出 9 种基因型。最常见的基因型为 E（25.16%，77/306），其次是 J（22.55%，69/306）、F（17%，52/306）、D（14.4%，44/306）、K（7.2%，22/306）、G（6.9%，21/306）、H（5.2%，16/306）、B（1.0%，3/306）、Ia（0.7%，2/306）。基因型 H 与异常宫颈细胞学有关[ = 0.006，比值比（OR）=8.16（1.86-36.6）]。然而，本研究未观察到 基因型与任何生殖器临床症状之间的关联。
基因型 H 可能是宫颈上皮内病变的高风险因素，这对宫颈上皮内病变患者的治疗和管理措施具有重要意义。
