从一名健康男性个体的外周血单个核细胞中生成无整合诱导多能干细胞系（KSCBi017-A）。
Generation of integration-free induced pluripotent stem cell line (KSCBi017-A) from peripheral blood mononuclear cells of a healthy male individual.
作者信息
Sam Im Young, Hoon Yoo Dae, Kim Hyung-Eun, Young Oh Ji, Kim Yong-Ou
机构信息
Division of Intractable Diseases Research, Korea National Institute of Health, Osong, Cheongju-si, South Korea.
Division of Intractable Diseases Research, Korea National Institute of Health, Osong, Cheongju-si, South Korea.
出版信息
Stem Cell Res. 2022 Dec;65:102965. doi: 10.1016/j.scr.2022.102965. Epub 2022 Nov 11.
A human induced pluripotent stem cell (hiPSC) line, KSCBi017-A, was generated from a 50-year-old male individual using non-integrating episomal vectors expressing reprogramming factors. The generated hiPSCs were integration-free, expressed pluripotency markers, exhibited the potential for differentiation into three germ layers in vivo, and maintained the normal karyotype. This cell line can be used as a control for a disease model and is available from Korea National Stem Cell Bank.
一种人诱导多能干细胞（hiPSC）系KSCBi017-A，是使用表达重编程因子的非整合型附加体载体从一名50岁男性个体中产生的。所产生的hiPSC无整合，表达多能性标志物，在体内表现出分化为三个胚层的潜力，并维持正常核型。该细胞系可作为疾病模型的对照，可从韩国国家干细胞库获得。
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