Franco Pablo Igor Ribeiro, do Carmo Neto José Rodrigues, Milhomem Anália Cirqueira, Machado Juliana Reis, Miguel Marina Pacheco
Instituto de Patologia Tropical e Saúde Pública, Laboratório de Histotécnica e Inovação, Centro Multiusuário de Pesquisa de Bioinsumos, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Instituto de Patologia Tropical e Saúde Pública, Laboratório de Histotécnica e Inovação, Centro Multiusuário de Pesquisa de Bioinsumos, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Biochim Biophys Acta Rev Cancer. 2023 Jan;1878(1):188838. doi: 10.1016/j.bbcan.2022.188838. Epub 2022 Nov 18.
Breast cancer is the most frequent malignant neoplasm in females. While conventional treatments such as chemotherapy and radiotherapy are available, they are highly invasive and toxic to oncological patients. Melatonin is a promising molecule for the treatment of breast cancer with antitumor effects on tumorigenesis and tumor progression. The aim of this systematic review was to synthesize knowledge about the antitumor effect of melatonin on breast cancer in experimental models and propose the main mechanisms of action already described in relation to the processes regulated by melatonin. PubMed, Web of Science, and Embase databases were used. The inclusion criteria were in vitro and in vivo experimental studies that used different formulations of melatonin as a treatment for breast cancer, without year or language restrictions. Risk of bias for studies was assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool. Data from selected articles were presented as narrative descriptions and tables. Seventy-five articles on different breast cancer cell lines and experimental models treated with melatonin alone, or in combination with other compounds were included. Melatonin showed antitumor effects on proliferative pathways related to the cell cycle and tumorigenesis, tumor death, angiogenesis, and tumor metastasis, as well as on oxidative stress and immune regulatory pathways. These effects were either dependent or independent of melatonin receptors. Herein, we clarify the antitumor action of melatonin on different tumorigenic processes in breast cancer in experimental models. Systematic review registration: PROSPERO database (CRD42022309822/https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022309822).
乳腺癌是女性中最常见的恶性肿瘤。虽然有化疗和放疗等传统治疗方法，但它们对肿瘤患者具有高度侵袭性和毒性。褪黑素是一种有前景的分子，对乳腺癌的发生和进展具有抗肿瘤作用，可用于治疗乳腺癌。本系统评价的目的是综合关于褪黑素在实验模型中对乳腺癌抗肿瘤作用的知识，并提出已报道的与褪黑素调节过程相关的主要作用机制。使用了PubMed、科学网和Embase数据库。纳入标准为体外和体内实验研究，这些研究使用不同剂型的褪黑素治疗乳腺癌，无年份或语言限制。使用实验室动物实验系统评价中心（SYRCLE）工具评估研究的偏倚风险。所选文章的数据以叙述性描述和表格形式呈现。纳入了75篇关于单独使用褪黑素或与其他化合物联合使用褪黑素治疗不同乳腺癌细胞系和实验模型的文章。褪黑素对与细胞周期、肿瘤发生、肿瘤死亡、血管生成和肿瘤转移相关的增殖途径以及氧化应激和免疫调节途径均显示出抗肿瘤作用。这些作用要么依赖于褪黑素受体，要么独立于褪黑素受体。在此，我们阐明了褪黑素在实验模型中对乳腺癌不同致瘤过程的抗肿瘤作用。系统评价注册：PROSPERO数据库（CRD42022309822/https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022309822）。
