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一生中的脑储备、复原力和认知刺激:这些因素如何影响认知障碍和痴呆症的风险?

Brain Reserve, Resilience, and Cognitive Stimulation Across the Lifespan: How Do These Factors Influence Risk of Cognitive Impairment and the Dementias?

作者信息

Sorond Farzaneh A, Gorelick Philip B

机构信息

Department of Neurology, Division of Stroke, Northwestern University, Feinberg School of Medicine, 625 North Michigan Avenue, 11th Floor, Chicago, IL 60611, USA.

Department of Neurology, Division of Stroke, Northwestern University, Feinberg School of Medicine, 625 North Michigan Avenue, 11th Floor, Chicago, IL 60611, USA.

出版信息

Clin Geriatr Med. 2023 Feb;39(1):151-160. doi: 10.1016/j.cger.2022.08.003.

DOI:10.1016/j.cger.2022.08.003
PMID:36404028
Abstract

In the absence of effective treatments for dementia, maintaining cognitive health in old age is one of the major challenges facing aging societies. Interventions for cognitive health that are tailored to the person are more likely to bring the best benefits with a minimum burden. We review the existing literature on this topic and discuss the role of the primary care physician.

摘要

在缺乏有效治疗痴呆症方法的情况下,保持老年人的认知健康是老龄化社会面临的主要挑战之一。针对个人量身定制的认知健康干预措施更有可能以最小的负担带来最大的益处。我们回顾了关于这一主题的现有文献,并讨论了初级保健医生的作用。

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Brain Reserve, Resilience, and Cognitive Stimulation Across the Lifespan: How Do These Factors Influence Risk of Cognitive Impairment and the Dementias?一生中的脑储备、复原力和认知刺激:这些因素如何影响认知障碍和痴呆症的风险?
Clin Geriatr Med. 2023 Feb;39(1):151-160. doi: 10.1016/j.cger.2022.08.003.
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Alzheimers Res Ther. 2019 Mar 11;11(1):22. doi: 10.1186/s13195-019-0479-y.
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Improving the resistance and resilience framework for aging and dementia studies.改善衰老和痴呆研究的抗性和弹性框架。
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What are the earlier life contributions to reserve and resilience?早期生活对储备和适应力有哪些贡献?
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Exploring strategies to operationalize cognitive reserve: A systematic review of reviews.探索实现认知储备的策略:综述的系统评价
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Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups.神经退行性疾病储备的转化研究:认知储备在痴呆症和阿尔茨海默病协会储备、韧性和保护因素专业兴趣领域工作组国际会议的共识报告。
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Brain reserve, cognitive reserve, compensation, and maintenance: operationalization, validity, and mechanisms of cognitive resilience.脑储备、认知储备、代偿和维持:认知弹性的操作性定义、有效性和机制。
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引用本文的文献

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Resilience and brain health in global populations.全球人群的复原力与大脑健康。
Nat Med. 2025 Jul 29. doi: 10.1038/s41591-025-03846-w.
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The Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for specialty care.阿尔茨海默病协会关于疑似阿尔茨海默病及相关疾病的诊断评估、检测、咨询与信息披露的临床实践指南(DETeCD - ADRD):专科护理建议执行摘要
Alzheimers Dement. 2025 Jan;21(1):e14337. doi: 10.1002/alz.14337. Epub 2024 Dec 23.
3
Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for primary care.
阿尔茨海默病协会关于疑似阿尔茨海默病及相关疾病的诊断评估、检测、咨询与信息披露的临床实践指南(DETeCD - ADRD):初级保健建议执行摘要
Alzheimers Dement. 2024 Dec 23. doi: 10.1002/alz.14333.
4
Introduction to the special issue on brain health.脑健康特刊引言。
Cereb Circ Cogn Behav. 2024 Jan 18;6:100208. doi: 10.1016/j.cccb.2024.100208. eCollection 2024.
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Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration.阿尔茨海默病的治疗开发:将神经退行性病变转向神经再生。
Trends Pharmacol Sci. 2024 Mar;45(3):197-209. doi: 10.1016/j.tips.2024.01.012. Epub 2024 Feb 14.
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What is brain health?什么是大脑健康?
Cereb Circ Cogn Behav. 2023 Oct 25;6:100190. doi: 10.1016/j.cccb.2023.100190. eCollection 2024.