Oregon Health & Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA.
Oregon Health & Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA.
Vaccine. 2022 Nov 22;40(49):7097-7107. doi: 10.1016/j.vaccine.2022.09.040. Epub 2022 Oct 28.
Parent and child vaccination behavior is related for human papillomavirus (HPV) and flu vaccine. Thus, it is likely that parental vaccination status is also associated with their children's adherence to guideline-concordant childhood vaccination schedules. We hypothesized that parent influenza (flu) vaccination would be associated with their child's vaccination status at age two.
We used electronic health record data to identify children and linked parents seen in a community health center (CHC) within the OCHIN network (292 CHCs in 16 states). We randomly selected a child aged <2 years with ≥1 ambulatory visit between 2009-2018. Employing a retrospective, cohort study design, we used general estimating equations logistic regression to estimate the odds of a child being up-to-date on vaccinations based on their linked parents' flu vaccination status. We adjusted for relevant parent and child covariates and stratified by mother only, father only, and two-parent samples.
The study included 40,007 family-units: mother only = 35,444, father only = 2,784, and two parents = 1,779. A higher percentage of children were fully vaccinated if their parent or parents received a flu vaccine. Children in the two-parent sample whose parents both received a flu vaccine had more than twice the odds of being fully vaccinated, and two and a half times the odds of being fully vaccinated except flu vaccine compared to children with two parents who did not receive a flu vaccine (covariate-adjusted odds ratio [aOR] = 2.39, 95% CI = 1.67, 3.43 and aOR = 2.54, 95% CI = 1.54, 4.19, respectively).
Parent flu vaccination is associated with routine child vaccination. Future research is needed to understand if this relationship persists over time and in different settings.
父母和子女的疫苗接种行为与人类乳头瘤病毒（HPV）和流感疫苗有关。因此，父母的疫苗接种状况也可能与子女遵循指南一致的儿童疫苗接种时间表有关。我们假设父母流感（flu）疫苗接种与他们孩子两岁时的疫苗接种状况有关。
我们使用电子健康记录数据来识别在 OCHIN 网络中的社区卫生中心（CHC）就诊的儿童及其关联父母（16 个州的 292 个 CHC）。我们随机选择一名年龄<2 岁且在 2009-2018 年期间有≥1 次门诊就诊的儿童。采用回顾性队列研究设计，我们使用一般估计方程逻辑回归来估计根据其关联父母的流感疫苗接种状况，儿童接种疫苗的几率。我们调整了相关的父母和子女协变量，并按母亲、父亲和双亲样本进行分层。
该研究包括 40,007 个家庭单位：母亲单独 = 35,444 个，父亲单独 = 2,784 个，双亲 = 1,779 个。如果其父母或父母接种了流感疫苗，儿童的完全接种率更高。在双亲样本中，如果父母双方都接种了流感疫苗，儿童完全接种疫苗的几率是父母双方都未接种流感疫苗的两倍多，除流感疫苗外，完全接种疫苗的几率是父母双方都未接种流感疫苗的 2.5 倍以上（调整后的协变量比值比[aOR] = 2.39，95%CI = 1.67, 3.43 和 aOR = 2.54，95%CI = 1.54, 4.19）。
父母流感疫苗接种与常规儿童疫苗接种有关。需要进一步研究以了解这种关系是否随着时间的推移和在不同环境中持续存在。
