Xu Yuanyuan, Wang Chengjin, Yang Yang, Liu Hui, Xiong Zhuo, Zhang Ting, Sun Wei
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, China.
Int J Bioprint. 2022 Sep 19;8(4):617. doi: 10.18063/ijb.v8i4.617. eCollection 2022.
Three-dimensional (3D) bioprinting offers a potentially powerful new approach to reverse engineering human pathophysiology to address the problem of developing more biomimetic experimental systems. Human tissues and organs are multiscale and multi-material structures. The greatest challenge for organ printing is the complexity of the structural elements, from the shape of the macroscopic structure to the details of the nanostructure. A highly bionic tissue-organ model requires the use of multiple printing processes. Some printers with multiple nozzles and multiple processes are currently reported. However, the bulk volume, which is inconvenient to move, and the high cost of these printing systems limits the expansion of their applications. Scientists urgently need a multifunctional miniaturized 3D bioprinter. In this study, a portable multifunctional 3D bioprinting system was built based on a modular design and a custom written operating application. Using this platform, constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs were successfully printed using commercial polymers and a series of hydrogel-based inks. With further development, this portable, modular, low-cost, and easy-to-use Bluetooth-enabled 3D printer promises exciting opportunities for resource-constrained application scenarios, not only in biomedical engineering but also in the education field, and may be used in space experiments.
三维（3D）生物打印提供了一种潜在的强大新方法，用于逆向工程人类病理生理学，以解决开发更多仿生实验系统的问题。人体组织和器官是多尺度和多材料结构。器官打印面临的最大挑战是结构元件的复杂性，从宏观结构的形状到纳米结构的细节。高度仿生的组织 - 器官模型需要使用多种打印工艺。目前有一些关于具有多个喷嘴和多种工艺的打印机的报道。然而，这些打印系统体积庞大、移动不便且成本高昂，限制了其应用的扩展。科学家迫切需要一种多功能小型化3D生物打印机。在本研究中，基于模块化设计和自定义编写的操作应用程序构建了一种便携式多功能3D生物打印系统。利用该平台，使用商业聚合物和一系列水凝胶基墨水成功打印出具有详细表面结构、中空结构和多尺度复杂组织类似物的构建体。随着进一步发展，这种便携式、模块化、低成本且易于使用的蓝牙3D打印机不仅在生物医学工程领域，而且在教育领域，为资源受限的应用场景带来了令人兴奋的机会，并且可能用于太空实验。
