产丁酸厚壁菌在2型糖尿病中的作用。
Role of butyrogenic Firmicutes in type-2 diabetes.
作者信息
James Meenu Mariya, Pal Namrata, Sharma Poonam, Kumawat Manoj, Shubham Swasti, Verma Vinod, Tiwari Rajnarayan R, Singh Birbal, Nagpal Ravinder, Sarma Devojit Kumar, Kumar Manoj
机构信息
ICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, 462030 Bhouri, Bhopal, Madhya Pradesh India.
Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, 226014 Lucknow, Uttar Pradesh India.
出版信息
J Diabetes Metab Disord. 2022 Jul 14;21(2):1873-1882. doi: 10.1007/s40200-022-01081-5. eCollection 2022 Dec.
OBJECTIVE
The aim of this review is to speculate the pre-clinical and clinical evidences indicating the association between butyrate-synthesizing firmicutes and development and progression of type 2 diabetes mellitus.
METHODOLOGY
Literature was searched using 'Google Scholar' and 'PubMed' to find out most relevant articles for the scope of this review. Information was also gathered from authentic sources such as the World Health Organisation and the International Diabetes Federation.
RESULTS
Evidences suggest that an abnormal perturbation in the gut microbiome characterized by subsided levels of butyrate-producing bacteria may gradually result in the progression of type-2 diabetes; however, the explicit mechanisms underlying and implicating the role of specific butyrate-producing microbes remain unclear.
CONCLUSIONS
This review explicitly summarizes the role of butyrate-synthesizing firmicutes known to be reduced in the subjects with type-2 diabetes mellitus in host metabolic health and contemplates the putative and reported mechanisms underlying its implication in the pathophysiology of type-2 diabetes mellitus.
目的
本综述旨在推测表明丁酸盐合成厚壁菌与2型糖尿病发生发展之间关联的临床前和临床证据。
方法
使用“谷歌学术”和“PubMed”搜索文献，以找出与本综述范围最相关的文章。还从世界卫生组织和国际糖尿病联合会等可靠来源收集信息。
结果
有证据表明，以产生丁酸盐的细菌水平下降为特征的肠道微生物群异常扰动可能会逐渐导致2型糖尿病的进展；然而，特定产丁酸盐微生物的潜在作用及其明确机制仍不清楚。
结论
本综述明确总结了已知在2型糖尿病患者中减少的丁酸盐合成厚壁菌在宿主代谢健康中的作用，并思考了其在2型糖尿病病理生理学中作用的假定机制和已报道机制。
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