Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai 201508, China.
Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Mar Drugs. 2024 Sep 2;22(9):401. doi: 10.3390/md22090401.
Seaweed extracts, especially fucoidan, are well known for their immune-modulating abilities. In this current study, we extracted fucoidan from , a seaweed commonly found in coastal Asia, and examined its anti-inflammatory effect. Fucoidan was extracted from dried (FCC) using an alcohol extraction method at an extraction rate of 4.5 ± 0.21%. The extracted FCC comprised the highest proportion of carbohydrates, along with sulfate and uronic acid. The immune regulatory effect of FCC was examined using bone marrow-derived dendritic cells (BMDCs). Pretreatment with FCC dose-dependently decreased the lipopolysaccharide (LPS)-induced upregulation of co-stimulatory molecules and major histocompatibility complex. In addition, FCC prevented morphological changes in LPS-induced BMDCs. Moreover, treatment of LPS-induced BMDCs with FCC suppressed the secretion of pro-inflammatory cytokines. In C57BL/6 mice, oral administration of FCC suppressed LPS-induced lung inflammation, reducing the secretion of pro-inflammatory cytokines in the bronchoalveolar lavage fluid. Finally, the administration of FCC suppressed LPS-induced sepsis. Therefore, FCC could be developed as a health supplement based on the observed anti-inflammatory effects.
海藻提取物，特别是褐藻糖胶，因其具有免疫调节能力而广为人知。在本研究中，我们从亚洲沿海常见的海藻中提取了褐藻糖胶，并研究了其抗炎作用。褐藻糖胶是通过醇提方法从干 （FCC） 中提取的，提取率为 4.5±0.21%。提取的 FCC 含有最高比例的碳水化合物、硫酸盐和糖醛酸。使用骨髓来源的树突状细胞（BMDC）研究了 FCC 的免疫调节作用。FCC 预处理呈剂量依赖性地降低脂多糖（LPS）诱导的共刺激分子和主要组织相容性复合体的上调。此外，FCC 防止 LPS 诱导的 BMDC 的形态变化。此外，用 FCC 处理 LPS 诱导的 BMDC 可抑制促炎细胞因子的分泌。在 C57BL/6 小鼠中，FCC 的口服给药抑制 LPS 诱导的肺部炎症，减少支气管肺泡灌洗液中促炎细胞因子的分泌。最后，FCC 的给药抑制 LPS 诱导的败血症。因此，基于观察到的抗炎作用，FCC 可开发为保健品。
