Almehmadi Lamyaa M, Lednev Igor K
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Department of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, New York 12222, United States.
J Phys Chem C Nanomater Interfaces. 2024 Sep 24;128(43):18135-18143. doi: 10.1021/acs.jpcc.4c04006. eCollection 2024 Oct 31.
Personalized medicine and drug discovery are different, yet overlapping, fields, and information from each field is exchanged to improve the other. The current methods used for devising personalized therapeutic plans and developing drug discovery applications are costly, time-consuming, and complex; thus, their applicability is limited in both fields. However, surface-enhanced Raman spectroscopy (SERS) offers potential solutions to current challenges. This Mini-Review explores the utility of SERS in drug discovery and personalized medicine. The Mini-Review starts with a brief overview of these fields, including the main challenges and current methods, and then explores examples where SERS has been used to overcome some of the main challenges in both fields. It ends with brief conclusions, perspectives, and current challenges limiting the practical application of SERS.
个性化医疗和药物研发是不同但又相互重叠的领域，两个领域之间会交流信息以促进彼此发展。目前用于制定个性化治疗方案和开发药物研发应用的方法成本高昂、耗时且复杂，因此，它们在这两个领域的适用性都受到限制。然而，表面增强拉曼光谱（SERS）为当前的挑战提供了潜在的解决方案。本综述探讨了SERS在药物研发和个性化医疗中的应用。综述首先简要概述了这些领域，包括主要挑战和当前方法，然后探讨了SERS用于克服这两个领域中一些主要挑战的实例。最后给出了简要结论、观点以及限制SERS实际应用的当前挑战。
