Zhou Juntuo, Zhong Lijun
Beijing Boyuan Precision Medicine Co., Ltd., Beijing, China.
Center of Medical and Health Analysis, Peking University Health Science Center, Beijing, China.
Front Mol Biosci. 2022 Nov 3;9:1049016. doi: 10.3389/fmolb.2022.1049016. eCollection 2022.
Metabolomics is a fast-developing technique used in biomedical researches focusing on pathological mechanism illustration or novel biomarker development for diseases. The ability of simultaneously quantifying thousands of metabolites in samples makes metabolomics a promising technique in predictive or personalized medicine-oriented researches and applications. Liquid chromatography-mass spectrometry is the most widely employed analytical strategy for metabolomics. In this current mini-review, we provide a brief update on the recent developments and novel applications of LC-MS based metabolomics in the predictive and personalized medicine sector, such as early diagnosis, molecular phenotyping or prognostic evaluation. COVID-19 related metabolomic studies are also summarized. We also discuss the prospects of metabolomics in precision medicine-oriented researches, as well as critical issues that need to be addressed when employing metabolomic strategy in clinical applications.
代谢组学是一种快速发展的技术，用于生物医学研究，专注于阐释病理机制或开发疾病的新型生物标志物。能够同时对样本中的数千种代谢物进行定量分析，使得代谢组学在面向预测性或个性化医学的研究与应用中成为一项很有前景的技术。液相色谱-质谱联用是代谢组学中应用最广泛的分析策略。在本篇综述中，我们简要介绍了基于液相色谱-质谱联用的代谢组学在预测性和个性化医学领域的最新进展和新应用，如早期诊断、分子表型分析或预后评估。还总结了与2019冠状病毒病相关的代谢组学研究。我们也讨论了代谢组学在面向精准医学研究中的前景，以及在临床应用中采用代谢组学策略时需要解决的关键问题。
