Shim YongSoo, Yang Dong Won, Ho SeongHee, Hong Yun Jeong, Jeong Jee Hyang, Park Kee Hyung, Kim SangYun, Wang Min Jeong, Choi Seong Hye, Kang Seung Wan
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.
Dement Neurocogn Disord. 2022 Oct;21(4):126-137. doi: 10.12779/dnd.2022.21.4.126. Epub 2022 Oct 25.
Early detection of subjective cognitive decline (SCD) due to Alzheimer's disease (AD) is important for clinical research and effective prevention and management. This study examined if quantitative electroencephalography (qEEG) could be used for early detection of AD in SCD.
Participants with SCD from 6 dementia clinics in Korea were enrolled. F-florbetaben brain amyloid positron emission tomography (PET) was conducted for all the participants. qEEG was performed to measure power spectrum and source cortical activity.
The present study included 95 participants aged over 65 years, including 26 amyloid PET (+) and 69 amyloid PET (-). In participants with amyloid PET (+), relative power at delta band was higher in frontal (=0.025), parietal (=0.005), and occipital (=0.022) areas even after adjusting for age, sex, and education. Source activities of alpha 1 band were significantly decreased in the bilateral fusiform and inferior temporal areas, whereas those of delta band were increased in the bilateral cuneus, pericalcarine, lingual, lateral occipital, precuneus, posterior cingulate, and isthmus areas. There were increased connections between bilateral precuneus areas but decreased connections between left rostral middle frontal area and bilateral frontal poles at delta band in participants with amyloid PET (+) showed. At alpha 1 band, there were decreased connections between bilateral entorhinal areas after adjusting for covariates.
SCD participants with amyloid PET (+) showed increased delta and decreased alpha 1 activity. qEEG is a potential means for predicting amyloid pathology in SCD. Further longitudinal studies are needed to confirm these findings.
早期发现由阿尔茨海默病（AD）引起的主观认知下降（SCD）对于临床研究以及有效的预防和管理至关重要。本研究探讨了定量脑电图（qEEG）是否可用于SCD中AD的早期检测。
招募了来自韩国6家痴呆症诊所的SCD参与者。对所有参与者进行了F-氟代苯并噻唑脑淀粉样蛋白正电子发射断层扫描（PET）。进行qEEG以测量功率谱和皮质源活动。
本研究纳入了95名年龄超过65岁的参与者，其中26名淀粉样蛋白PET（+），69名淀粉样蛋白PET（-）。在淀粉样蛋白PET（+）的参与者中，即使在调整年龄、性别和教育程度后，额叶（=0.025）、顶叶（=0.005）和枕叶（=0.022）区域的δ频段相对功率仍较高。α1频段的源活动在双侧梭状回和颞下回区域显著降低，而δ频段的源活动在双侧楔叶、距状裂周围、舌回、枕外侧、楔前叶、后扣带回和峡部区域增加。淀粉样蛋白PET（+）的参与者在δ频段显示双侧楔前叶区域之间的连接增加，但左侧额中回喙部区域与双侧额极之间的连接减少。在α1频段，调整协变量后双侧内嗅区之间的连接减少。
淀粉样蛋白PET（+）的SCD参与者表现出δ活动增加和α1活动减少。qEEG是预测SCD中淀粉样蛋白病理的一种潜在手段。需要进一步的纵向研究来证实这些发现。
