德国献血人群中细小病毒 B19 血症的流行情况及其与 ABO 和 Rh 血型抗原的关系。
Prevalence of Parvovirus B19 Viremia Among German Blood Donations and the Relationship to ABO and Rhesus Blood Group Antigens.
机构信息
Division of Clinical Diagnostics and Surgery, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
出版信息
J Infect Dis. 2023 May 12;227(10):1214-1218. doi: 10.1093/infdis/jiac456.
BACKGROUND
Asymptomatic blood donors can transmit human parvovirus B19 (B19V).
METHODS
We assessed the B19V prevalence among a large cohort of blood donations collected in Germany during 2015-2018.
RESULTS
In total, 167 123 donations were screened for B19V deoxyribonucleic acid with 22 cases of viremia identified (0.013% positive). Infections peaked at a 4-year interval and the highest number of cases occurred in the summer months. All 22 infections were found in rhesus D-antigen-positive donations, suggesting a protective factor in donors who lack this antigen.
CONCLUSIONS
These findings contribute to our understanding of risk factors for B19V infection among central European blood and plasma donors.
背景
无症状献血者可能传播人细小病毒 B19（B19V）。
方法
我们评估了 2015 年至 2018 年间在德国采集的大量献血样本中 B19V 的流行情况。
结果
总共筛查了 167123 份血液样本以检测 B19V 脱氧核糖核酸，发现 22 例病毒血症（阳性率 0.013%）。感染高峰出现在 4 年间隔，夏季病例数最多。所有 22 例感染均发生在 RhD 抗原阳性的献血者中，表明缺乏这种抗原的献血者存在保护因素。
结论
这些发现有助于我们了解中欧血液和血浆献血者 B19V 感染的危险因素。
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