Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.
Department of Biological Sciences, Pusan National University, Busan 46241, Korea.
Int J Mol Sci. 2022 Nov 10;23(22):13818. doi: 10.3390/ijms232213818.
Glioblastoma (GBM) is the most malignant primary brain tumor. Despite increasing research on GBM treatment, the overall survival rate has not significantly improved over the last two decades. Although recent studies have focused on aberrant metabolism in GBM, there have been few advances in clinical application. Thus, it is important to understand the systemic metabolism to eradicate GBM. Together with the Warburg effect, lipid metabolism has emerged as necessary for GBM progression. GBM cells utilize lipid metabolism to acquire energy, membrane components, and signaling molecules for proliferation, survival, and response to the tumor microenvironment. In this review, we discuss fundamental cholesterol, fatty acid, and sphingolipid metabolism in the brain and the distinct metabolic alterations in GBM. In addition, we summarize various studies on the regulation of factors involved in lipid metabolism in GBM therapy. Focusing on the rewiring of lipid metabolism will be an alternative and effective therapeutic strategy for GBM treatment.
胶质母细胞瘤（GBM）是最恶性的原发性脑肿瘤。尽管对 GBM 治疗的研究不断增加，但在过去的二十年中，总体生存率并没有显著提高。尽管最近的研究集中在 GBM 中的异常代谢上，但在临床应用方面进展甚微。因此，了解系统代谢对于根除 GBM 非常重要。与瓦伯格效应一起，脂代谢已成为 GBM 进展所必需的。GBM 细胞利用脂代谢获取能量、膜成分和信号分子，以进行增殖、存活和对肿瘤微环境的反应。在这篇综述中，我们讨论了大脑中基本的胆固醇、脂肪酸和鞘脂代谢以及 GBM 中的独特代谢改变。此外，我们总结了各种关于调节 GBM 治疗中脂质代谢相关因素的研究。关注脂代谢的重排将是 GBM 治疗的一种替代和有效的治疗策略。
