Jain Subir, Jain Ashutosh, Gupta Sanjay Kumar
ENT Centre, 106 Hari Amrit Palace, 12 Bhanvarkua, Opposite Anand Hospital, Indore, MP 452001 India.
Tutor, Department of Physiology, Index Medical College Hospital and Research Centre, Indore, India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):888-893. doi: 10.1007/s12070-020-01954-2. Epub 2020 Jul 13.
The prevalence of Allergic rhinitis (AR) is associated with a variety of environmental allergens and the level of exposure is through inhalation, or ingestion. It is clear from several studies and guidelines that screening and identification of various allergens in a particular region can facilitate in diagnosing, treating and formulating preventive strategies against AR. To study the allergen patterns in patients with Moderate to severe persistent allergic rhinitis from Central India. Male/female of 6 to 63 years age group, presenting with itching of the nose, sneezing, rhinorrhoea, nasal congestion and nasal obstruction. Patients suffering from infective pathology of nose and sinuses. The study group comprised of 1350 male/female of the age group between 6 and 63 years. Modified skin prick test was performed according to the method of Pepys and Bernstein. The ratio of allergen wheal and histamine wheal was used to evaluate the results. The reactions with wheal diameter 3 mm or greater than the reading in the negative control were considered as positive reaction. Results of the study indicate that in Central India, the common allergens are pollens (78.5%), insects (64.5%), dust (38.5%), dust mites (18%) and food (10%) causing moderate to severe persistent allergic rhinitis. The study provided an insight and identified the allergen pattern in Central India. The results were of great help in counseling for avoidance therapy and for deciding allergen specific immunotherapy which is the standard treatment protocol to modify natural course of allergic rhinitis at this point of time.
变应性鼻炎（AR）的患病率与多种环境过敏原相关，暴露途径为吸入或摄入。多项研究和指南表明，筛查和鉴定特定地区的各种过敏原有助于AR的诊断、治疗和制定预防策略。为研究印度中部中重度持续性变应性鼻炎患者的过敏原模式。年龄在6至63岁的男性/女性，表现为鼻痒、打喷嚏、流涕、鼻塞和鼻阻塞。患有鼻和鼻窦感染性病变的患者。研究组由1350名年龄在6至63岁之间的男性/女性组成。根据佩皮斯和伯恩斯坦的方法进行改良皮肤点刺试验。用过敏原风团与组胺风团的比值评估结果。风团直径3毫米或大于阴性对照读数的反应被视为阳性反应。研究结果表明，在印度中部，引起中重度持续性变应性鼻炎的常见过敏原为花粉（78.5%）、昆虫（64.5%）、灰尘（38.5%）、尘螨（18%）和食物（10%）。该研究提供了相关见解并确定了印度中部的过敏原模式。研究结果对指导避免疗法以及决定变应原特异性免疫疗法（这是目前改变变应性鼻炎自然病程的标准治疗方案）有很大帮助。
