*Guang'anmen Hospital, China Academy of Chinese Medical Sciences †Beijing Tongren Eye Center, Beijing Tongren Hospital ∥Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine ‡Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing §Department of Anatomy, Histology and Embryology, Peking University School of Basic Medical Sciences ¶Beijing University of Chinese Medicine, Beijing, PR China.
J Glaucoma. 2014 Jan;23(1):19-22. doi: 10.1097/IJG.0b013e31825afc9d.
To investigate whether patients with primary open-angle glaucoma combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise.
Prospective Control Clinical Study. Eighty eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally were categorized as per their degree of myopia (myopes 6 D or more, n=30 and between -0.76 and -5.99 D, n=29) or without myopia (n=21). Twenty-four-hour IOP fluctuations at resting conditions were observed in protocol 1, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) and followed by 5 minutes of exercise at 60% Wmax were observed in protocol 2.
Twenty-four-hour IOP fluctuations at resting conditions were not statistically significant among groups (P=0.58). After 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50±2.76 mm Hg) over other subjects (analysis of covariance, age, as a covariate, was controlled, P=0.02). After 5 minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57±3.47 mm Hg) than other groups (P=0.00).
High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.
研究原发性开角型青光眼合并高度近视（POAG-HM）患者在 24 小时内静息状态和动态运动后短期眼压（IOP）波动情况。
前瞻性对照临床研究。80 只眼的 80 例中国原发性开角型青光眼高压患者仅局部使用前列腺素类似物，根据近视程度（近视 6 度或以上，n=30；-0.76 至-5.99 度，n=29）或不近视（n=21）进行分类。方案 1 观察静息状态下 24 小时的 IOP 波动情况，方案 2 观察 10 分钟 20%最大瓦特（Wmax）运动后和 5 分钟 60%Wmax 运动后的 IOP 波动情况。
静息状态下 24 小时 IOP 波动在各组间无统计学意义（P=0.58）。经过 10 分钟的中度（20%Wmax）运动后，POAG-HM 患者的 IOP 显著下降（3.50±2.76mm Hg），与其他患者相比（协方差分析，年龄作为协变量，控制 P=0.02）。经过 5 分钟的剧烈（60%Wmax）运动后，POAG-HM 患者的运动后 IOP 下降明显更大（7.57±3.47mm Hg），与其他组相比（P=0.00）。
仅接受药物性青光眼治疗的高度近视高压 POAG 患者在中度和剧烈运动后 IOP 波动明显更大，但静息状态下 24 小时 IOP 波动并无增加。
