Lo Iacono Melania, Gaggianesi Miriam, Bianca Paola, Brancato Ornella Roberta, Muratore Giampaolo, Modica Chiara, Roozafzay Narges, Shams Kimiya, Colarossi Lorenzo, Colarossi Cristina, Memeo Lorenzo, Turdo Alice, Veschi Veronica, Di Franco Simone, Todaro Matilde, Stassi Giorgio
Department of Health Promotion Sciences, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, 90127 Palermo, Italy.
J Clin Med. 2022 Nov 26;11(23):6996. doi: 10.3390/jcm11236996.
In a scenario where eco-sustainability and a reduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. The presence of a heterogeneous cancer stem cell (CSC) population within a tumor bulk is related to disease recurrence and therapy resistance. For this reason, CSC targeting presents a promising strategy for hampering cancer recurrence. Increasing evidence shows that NPs can inhibit crucial signaling pathways involved in the maintenance of CSC stemness and sensitize CSCs to standard chemotherapeutic treatments. Moreover, their limited toxicity and low costs for large-scale production could accelerate the use of NPs in clinical settings. In this review, we will summarize the most relevant studies regarding the effects of NPs derived from major natural sources, e.g., food, botanical, and marine species, on CSCs, elucidating their use in pre-clinical and clinical studies.
在生态可持续性以及减少化疗药物废弃物无疑是保护生物圈的先决条件的情况下，使用天然产物（NP）代表了一种对抗癌症疾病的替代治疗方法。肿瘤块内存在异质性癌症干细胞（CSC）群体与疾病复发和治疗抗性有关。因此，靶向CSC是一种有前景的阻碍癌症复发的策略。越来越多的证据表明，NP可以抑制参与维持CSC干性的关键信号通路，并使CSC对标准化疗治疗敏感。此外，它们有限的毒性和大规模生产的低成本可以加速NP在临床环境中的使用。在这篇综述中，我们将总结关于源自主要天然来源（如食物、植物和海洋物种）的NP对CSC影响的最相关研究，阐明它们在临床前和临床研究中的应用。
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