补充提取物对通过脂质转运的小鼠耐力运动和耗能过程的影响。
Effect of Extract Supplementation on Endurance Exercise and Energy-Consuming Processes through Lipid Transport in Mice.
机构信息
Department of Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei City 11031, Taiwan.
出版信息
Nutrients. 2022 Nov 25;14(23):5007. doi: 10.3390/nu14235007.
(IO) is used as functional food to treat diabetes. This study investigated the effect of IO supplementation on body composition in relation to changes in energy expenditure and exercise performance. Male Institute of Cancer Research mice were divided into four groups ( = 8 per group) and orally administered IO once daily for 6 wk at 0 (vehicle), 824 (IO-1×), 1648 (IO-2×), and 2472 mg/kg (IO-3×). IO supplementation increased muscle volume, exhaustive treadmill time, and glycogen storage in mice. Serum free fatty acid levels after acute exercise improved in the IO supplementation group, which exhibited changes in energy expenditure through the peroxisome proliferator-activated receptor (PPAR) pathway. RNA sequencing revealed significantly increased PPAR signaling; phenylalanine, ascorbate, aldarate, and cholesterol metabolism; chemical carcinogenesis; and ergosterol biosynthesis in the IO group compared with the vehicle group. Thus, IO supplements as nutraceuticals have a positive effect on lipid transport and exercise performance. In addition, this study was only IO supplementation without training-related procedures.
（IO）被用作功能性食品来治疗糖尿病。本研究调查了 IO 补充剂对身体成分的影响，以及对能量消耗和运动表现的变化。雄性癌症研究所小鼠被分为四组（每组 8 只），每日口服 IO 一次，连续 6 周，剂量分别为 0（载体）、824（IO-1×）、1648（IO-2×）和 2472 mg/kg（IO-3×）。IO 补充剂增加了小鼠的肌肉体积、耗尽跑步机的时间和糖原储存。急性运动后血清游离脂肪酸水平在 IO 补充组中得到改善，这通过过氧化物酶体增殖物激活受体（PPAR）途径改变了能量消耗。与对照组相比，IO 组的 RNA 测序显示 PPAR 信号显著增加；苯丙氨酸、抗坏血酸、醛酸盐和胆固醇代谢；化学致癌作用；以及麦角固醇生物合成。因此，IO 补充剂作为营养保健品对脂质转运和运动表现有积极影响。此外，本研究仅为 IO 补充剂，不涉及与训练相关的程序。
Zotero 插件