Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Department of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Front Endocrinol (Lausanne). 2023 Jan 6;13:1103972. doi: 10.3389/fendo.2022.1103972. eCollection 2022.
Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties. In this research, we aim to investigate the potential treatment outcomes of for T2DM and discuss its favourable influences on the intestinal flora. The chemical composition of methanol extracts (IO) was analyzed by ultra-high-performance liquid chromatography-Q extractive-mass spectrometry. IO significantly improved the blood glucose level, blood lipid level, and inflammatory factor level in T2DM mice, and effectively alleviated the morphological changes of colon, liver and renal. Acetic acid, propionic acid, and butyric acid levels in the feces of the IO group were restored. 16S rRNA gene sequencing revealed that the intestinal flora composition of mice in the IO group was significantly modulated. showed significant hypoglycemic and hypolipidemic effects with evident anti-inflammatory activity and improved the morphological structure of various organs and cells. increased the levels of short-chain fatty acids in the environment by increasing the population of certain bacteria that produce acid, such as and , which are beneficial to improve intestinal flora disorders and maintain intestinal flora homeostasis. Meanwhile, further alleviated T2DM symptoms in db/db mice by down-regulating the high number of microorganisms that are dangerous, such as and and up-regulating the abundance of beneficial bacteria such as and . Therefore, this study provides a new perspective for the treatment of T2DM by demonstrating that drug and food homologous active substances could relieve inflammation regulating intestinal flora.
2 型糖尿病（T2DM）对人类健康构成重大威胁。先前的研究表明， 具有良好的降血脂、抗炎和抗肿瘤特性。在这项研究中，我们旨在研究 治疗 T2DM 的潜在疗效，并探讨其对肠道菌群的有利影响。采用超高效液相色谱-萃取质谱法分析 的甲醇提取物（IO）的化学成分。IO 显著改善了 T2DM 小鼠的血糖、血脂和炎症因子水平，有效缓解了结肠、肝脏和肾脏的形态变化。IO 组粪便中的乙酸、丙酸和丁酸水平得到恢复。16S rRNA 基因测序显示，IO 组小鼠的肠道菌群组成发生了显著变化。 表现出显著的降血糖和降血脂作用，具有明显的抗炎活性，并改善了各种器官和细胞的形态结构。 通过增加产生酸的某些细菌的种群来增加环境中的短链脂肪酸水平，如 和 ，这有利于改善肠道菌群失调并维持肠道菌群平衡。同时， 进一步通过下调危险微生物如 和 ，并上调有益细菌如 和 的丰度，缓解 db/db 小鼠的 T2DM 症状。因此，这项研究通过证明药物和食品同源活性物质可以通过调节肠道菌群来缓解炎症，为 T2DM 的治疗提供了新的视角。
