Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Interdepartmental Center "Alma Mater Research Institute on Global Challenges and Climate Change (Alma Climate)", University of Bologna, Bologna, Italy.
Aging (Albany NY). 2021 Mar 17;13(6):7931-7942. doi: 10.18632/aging.202840.
Perilipin 2 (PLIN2) is a protein involved in lipid storage and metabolism in non-adipose tissues. Detectable levels of circulating PLIN2 (cPLIN2) have been reported to be associated with some types of cancer, but no systematic analysis of age-related modifications in cPLIN2 levels has ever been performed. We measured serum cPLIN2 in a group of old people including centenarians in comparison with young subjects and tested possible correlations with parameters of body composition, fat and glucose metabolism, and inflammation. We found that: i. levels of cPLIN2 do not change with age, but women have higher levels of cPLIN2 with respect to men; ii. cPLIN2 levels strongly correlate to BMI, as well as fat and lean mass; iii. cPLIN2 levels strongly correlate with the proinflammatory adipokine leptin. Due to the adipogenic activity of leptin, it is hypothesized that cPLIN2 is affected and possibly regulated by this pleiotropic adipokine. Moreover, these results suggest that cPLIN2 (possibly together with leptin) could be assumed as a proxy for body adiposity.
perilipin 2 (PLIN2) 是一种参与非脂肪组织中脂质储存和代谢的蛋白质。有报道称，循环 PLIN2 (cPLIN2) 的可检测水平与某些类型的癌症有关，但从未对 cPLIN2 水平与年龄相关的变化进行过系统分析。我们测量了一组老年人（包括百岁老人）与年轻人血清中的 cPLIN2，并测试了与身体成分、脂肪和葡萄糖代谢以及炎症参数的可能相关性。我们发现：i. cPLIN2 水平不随年龄变化，但女性的 cPLIN2 水平高于男性；ii. cPLIN2 水平与 BMI 以及脂肪和瘦体重强烈相关；iii. cPLIN2 水平与促炎脂肪因子瘦素强烈相关。由于瘦素的脂肪生成活性，据推测 cPLIN2 受到这种多效性脂肪因子的影响和可能的调节。此外，这些结果表明，cPLIN2（可能与瘦素一起）可作为体脂的替代指标。
