Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China; Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, People's Republic of China.
Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
Phytochemistry. 2023 Feb;206:113512. doi: 10.1016/j.phytochem.2022.113512. Epub 2022 Nov 26.
Eight unreported α-acyloxy amide substituted kalihinane diterpenes, named kalihiacyloxyamides A-H were isolated from the South China Sea sponge Acanthella cavernosa. The planar structures and absolute configurations were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis, single crystal X-ray diffraction and CD spectroscopic analysis. Two compounds showed significant cytotoxicity against K562 cell line with IC values of 6.4 and 6.3 μM, while two other compounds displayed moderate cytotoxicity against MDA-MB-231 with IC values of 7.3 and 7.9 μM.
从南海海绵 Acanthella cavernosa 中分离得到了 8 个未报道的α-酰氧基酰胺取代的卡利希纳二萜类化合物，命名为卡利希酰氧基酰胺 A-H。通过详细的 1D 和 2D NMR 实验以及 HRESIMS 分析、单晶 X 射线衍射和 CD 光谱分析，阐明了它们的平面结构和绝对构型。两种化合物对 K562 细胞系表现出显著的细胞毒性，IC 值分别为 6.4 和 6.3 μM，而另外两种化合物对 MDA-MB-231 表现出中等的细胞毒性，IC 值分别为 7.3 和 7.9 μM。
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