Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Mar Drugs. 2012 Jul;10(7):1445-1458. doi: 10.3390/md10071445. Epub 2012 Jul 2.
Seven new formamido-diterpenes, cavernenes A-D (1-4), kalihinenes E and F (5-6), and kalihipyran C (7), together with five known compounds (8-12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC(50) values in the range of 6-18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg/mL, respectively.
从南海海绵 Acanthella cavernosa 中分离得到了 7 种新的甲酰胺二萜类化合物 cavernenes A-D（1-4）、kalihinenes E 和 F（5-6）以及 kalihipyran C（7），以及 5 种已知化合物（8-12）。结构通过 IR、HRESIMS、1D 和 2D NMR 以及单晶 X 射线衍射技术确定。对分离得到的化合物进行了人癌细胞系（HCT-116、A549、HeLa、QGY-7701 和 MDA-MB-231）的细胞毒性评估，IC50 值在 6-18 μM 范围内。此外，化合物 9 对红色毛癣菌和石膏样小孢子菌具有较弱的抗真菌活性，MIC 值分别为 8 和 32 μg/mL，化合物 10 对白色念珠菌、新型隐球菌、红色毛癣菌和石膏样小孢子菌具有较弱的抗真菌活性，MIC 值分别为 8、8、4 和 8 μg/mL。
