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含抗生物膜物质的聚N-异丙基丙烯酰胺微凝胶对从慢性伤口分离出的（物质）的影响 。 注：原文结尾处“isolated from Chronic Wounds”前面应该还有相关物质，但原文未完整表述。

Effects of Poly-N-isopropylacrylamide Microgels Containing Antibiofilm Substances on Isolated from Chronic Wounds.

作者信息

Etemadinia Akram, Seyfoori Amir, Rahimi Foroushani Abbas, Mazaheri Nezhad Fard Ramin, Bakhtiari Ronak

机构信息

Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran, Iran.

Department of Biomaterials and Tissue Engineering, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.

出版信息

Avicenna J Med Biotechnol. 2022 Oct-Dec;14(4):317-320.

PMID:36504567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9706250/
Abstract

BACKGROUND

Biofilm formation helps () survive in various environments. Microgels can be effective in treatment of bacterial infections. The major aim of this study was to investigate effects of poly-N-isopropylacrylamide microgels (PNIPAM) on .

METHODS

Totally, 100 strains were isolated from chronic wound infections. Quantitative assessments of biofilm formation and antibiotic susceptibility were carried out. Furthermore, D, R, and 2714 genes were amplified to investigate gene frequencies and expression rates.

RESULTS

Significant decreases were seen in R expression in EDTA-treated samples. Significant decreases were observed in expression of D and R treated with xylitol. Decreased expression of 2714 was seen in samples treated with xylitol with no significance.

CONCLUSION

The PNIPAM containing xylitol or EDTA could penetrate biofilms of and significantly decrease expression of R and D. This can be a novel strategy in the management of chronic wounds.

摘要

背景

生物膜形成有助于（）在各种环境中生存。微凝胶可有效治疗细菌感染。本研究的主要目的是研究聚N-异丙基丙烯酰胺微凝胶（PNIPAM）对（）的影响。

方法

共从慢性伤口感染中分离出100株（）菌株。对生物膜形成和抗生素敏感性进行了定量评估。此外，扩增了D、R和2714基因以研究基因频率和表达率。

结果

在EDTA处理的样本中，R表达显著降低。用木糖醇处理的样本中，D和R的表达显著降低。用木糖醇处理的样本中2714的表达降低，但无显著性差异。

结论

含木糖醇或EDTA的PNIPAM可穿透（）的生物膜，并显著降低R和D的表达。这可能是慢性伤口管理中的一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/d5530021c5a9/AJMB-14-317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/323c1fffcd63/AJMB-14-317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/9ec628273611/AJMB-14-317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/5de714c71cb3/AJMB-14-317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/4e10e28bb14b/AJMB-14-317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/d5530021c5a9/AJMB-14-317-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/323c1fffcd63/AJMB-14-317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/9ec628273611/AJMB-14-317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/5de714c71cb3/AJMB-14-317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/4e10e28bb14b/AJMB-14-317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b340/9706250/d5530021c5a9/AJMB-14-317-g005.jpg

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