The performance evaluation of the state-of-the-art EEG-based seizure prediction models.

The recurrent and unpredictable nature of seizures can lead to unintentional injuries and even death. The rapid development of electroencephalogram (EEG) and Artificial Intelligence (AI) technologies has made it possible to predict seizures in real-time through brain-machine interfaces (BCI), allowing advanced intervention. To date, there is still much room for improvement in predictive seizure models constructed by EEG using machine learning (ML) and deep learning (DL). But, the most critical issue is how to improve the performance and generalization of the model, which involves some confusing conceptual and methodological issues. This review focuses on analyzing several factors affecting the performance of seizure prediction models, focusing on the aspects of post-processing, seizure occurrence period (SOP), seizure prediction horizon (SPH), and algorithms. Furthermore, this study presents some new directions and suggestions for building high-performance prediction models in the future. We aimed to clarify the concept for future research in related fields and improve the performance of prediction models to provide a theoretical basis for future applications of wearable seizure detection devices.