Mo@ZIF-8纳米酶的制备及其抗菌性能评估。
Mo@ZIF-8 nanozyme preparation and its antibacterial property evaluation.
作者信息
Lian Zheng, Lu Chunqing, Zhu Jiangqi, Zhang Xining, Wu Ting, Xiong Youlin, Sun Zhiyi, Yang Rong
机构信息
School of Criminal Investigation, People's Public Security University of China, Beijing, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, China.
出版信息
Front Chem. 2022 Nov 24;10:1093073. doi: 10.3389/fchem.2022.1093073. eCollection 2022.
Types of nanozymes can produce free radicals and/or reactive oxygen species (ROS) to serve as broad spectrum antibacterial materials. Developing nanozyme-based antibacterial materials with good biocompatibility exhibits promising application prospects. In this study, we doped Mo to ZIF-8 (both components have good biocompatibility) to prepare a new nanozyme, Mo@ZIF-8, which can produce hydroxyl radicals (•OH) triggered by a low dosage of hydrogen peroxide (HO), exhibiting effective antibacterial capability against both Gram-negative bacteria () and Gram-positive bacteria (). This work provides a reference for the design of antibacterial nanozymes with good biocompatibility.
纳米酶的类型可以产生自由基和/或活性氧（ROS），用作广谱抗菌材料。开发具有良好生物相容性的基于纳米酶的抗菌材料具有广阔的应用前景。在本研究中，我们将钼掺杂到ZIF-8中（两种成分都具有良好的生物相容性）以制备一种新型纳米酶Mo@ZIF-8，它可以由低剂量的过氧化氢（HO）触发产生羟基自由基（•OH），对革兰氏阴性菌（）和革兰氏阳性菌（）均表现出有效的抗菌能力。这项工作为设计具有良好生物相容性的抗菌纳米酶提供了参考。
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