Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329, USA.
Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, 30329, USA.
Antiviral Res. 2023 Jan;209:105490. doi: 10.1016/j.antiviral.2022.105490. Epub 2022 Dec 12.
Human infection with Sosuga virus (SOSV), a recently discovered pathogenic paramyxovirus, has been reported in one individual to date. No animal models of disease are currently available for SOSV. Here, we describe initial characterization of experimental infection in Syrian hamsters, including kinetics of virus dissemination and replication, and the corresponding clinical parameters, immunological responses, and histopathology. We demonstrate susceptibility of hamsters to infection in the absence of clinical signs or significant histopathologic findings in tissues.
迄今为止，仅在 1 例人类感染了 Sosuga 病毒（SOSV），这是一种最近发现的致病性副黏病毒。目前尚无用于 Sosuga 病毒的疾病动物模型。在此，我们描述了在叙利亚仓鼠中进行的实验性感染的初步特征，包括病毒传播和复制的动力学，以及相应的临床参数、免疫反应和组织病理学。我们证明了仓鼠在没有临床症状或组织病理学发现的情况下易感染。
