Comparative Medicine Branch, Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis. 2020 May 11;221(Suppl 4):S454-S459. doi: 10.1093/infdis/jiz552.
Nipah virus (NiV; family Paramyxoviridae, genus Henipavirus) infection can cause severe respiratory and neurological disease in humans. The pathophysiology of disease is not fully understood, and it may vary by presentation and clinical course. In this study, we investigate changes in blood chemistry in NiV-infected Syrian hamsters that survived or succumbed to disease. Increased sodium and magnesium and decreased albumin and lactate levels were detected in animals euthanized with severe clinical disease compared with mock-infected controls. When subjects were grouped by clinical syndrome, additional trends were discernable, highlighting changes associated with either respiratory or neurological disease.
尼帕病毒（NiV；副黏病毒科，亨尼帕病毒属）感染可导致人类严重的呼吸道和神经系统疾病。疾病的病理生理学尚未完全了解，其可能因表现和临床病程而异。在这项研究中，我们研究了幸存或死于疾病的感染尼帕病毒的叙利亚仓鼠的血液化学变化。与模拟感染对照相比，安乐死的患有严重临床疾病的动物的钠离子和镁离子增加，白蛋白和乳酸水平降低。当根据临床综合征对研究对象进行分组时，可以发现其他趋势，突出了与呼吸道或神经系统疾病相关的变化。
