Department of Surgery, Dentistry, Paediatrics and Gynaecology, Pain Therapy Center, University of Verona, 37124 Verona, Italy.
Department of Neurosciences, Biomedicine and Movement Sciences, Clinical Psychology, University of Verona, 37124 Verona, Italy.
Int J Environ Res Public Health. 2022 Dec 7;19(24):16395. doi: 10.3390/ijerph192416395.
Fibromyalgia Syndrome (FMS) is characterized by chronic widespread pain, fatigue, unrefreshing sleep and cognitive dysfunction. Depressive and manic symptoms are often reported in FMS patients' history. The aim of this study was to evaluate the prevalence of bipolar spectrum symptoms (BSS) and to correlate these with quality of life (QoL) scores and antidepressant treatment.
From October 2017 to July 2018, a battery of QoL questionnaires (FIQ, PSQI and SF-12) was administered to 120 FMS patients after a clinical examination. The MOODS-SR lifetime questionnaire was then remotely administered to the patients included in the study.
The presence of depressive and manic lifetime symptoms was found, in line with the results of the available literature. A correlation was found between the history of depressive symptoms and the severity of FIQ and SF-12 scores. Despite a low statistical strength, a trend toward a correlation between a history of manic symptoms and SNRI treatment was detected.
The correlation between the MOOD-depressive domains and poor QoL is in line with the available literature. Further studies are needed to corroborate these findings and to elucidate the relationship between manic symptoms and SNRI treatment.
纤维肌痛综合征（FMS）的特征为慢性广泛性疼痛、疲劳、睡眠不足和认知功能障碍。FMS 患者的病史中常报告有抑郁和躁狂症状。本研究旨在评估双相谱系症状（BSS）的患病率，并将其与生活质量（QoL）评分和抗抑郁治疗相关联。
2017 年 10 月至 2018 年 7 月，对 120 名 FMS 患者进行临床检查后，他们接受了一系列 QoL 问卷（FIQ、PSQI 和 SF-12）的评估。随后，远程向参与研究的患者发放 MOODS-SR 终生问卷。
研究结果与现有文献一致，发现了存在抑郁和躁狂终生症状。抑郁症状史与 FIQ 和 SF-12 评分的严重程度之间存在相关性。尽管统计强度较低，但检测到躁狂症状史与 SNRI 治疗之间存在相关性的趋势。
MOOD-抑郁领域与较差的 QoL 之间的相关性与现有文献一致。需要进一步的研究来证实这些发现，并阐明躁狂症状与 SNRI 治疗之间的关系。
