Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy.
Clin Exp Rheumatol. 2009 Sep-Oct;27(5 Suppl 56):S57-61.
We aimed at investigating the impact of lifetime manic spectrum symptoms on the severity of pain and the health-related quality of life (HRQoL) in patients with fibromyalgia (FM).
One hundred and sixty-seven patients with FM, assessed according to the ACR criteria, were consecutively enrolled. Psychiatric diagnoses were carried out following the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV-TR). The severity of pain and the HRQoL of FM patients was measured by means of the Fibromyalgia Impact Questionnaire (FIQ) and the Medical Outcomes Study Short Form-36 Health Survey (MOS SF-36); the mood spectrum symptomatology by means of the Mood Spectrum-Self Report (MOODS-SR).
A high rate of lifetime manic symptoms was detected and resulted as related to the Pain Visual Analogic Scale ("pain VAS") of the FIQ and the FIQ total scores as well as to the "bodily pain", and to the physical and mental component summary scores of the MOS SF-36, both in the whole sample (n=167) and in FM patients without bipolar disorder (n=160).
Our results highlight the need to pay more attention to manic spectrum symptoms and features in FM patients, because of their relationship with the severity of pain and with a worse HRQoL.
本研究旨在探讨躁狂谱系症状的终生发作对纤维肌痛（FM）患者疼痛严重程度和健康相关生活质量（HRQoL）的影响。
我们连续纳入了 167 名符合 ACR 标准的 FM 患者，并根据《精神障碍诊断与统计手册》（DSM-IV-TR）进行了精神科诊断。采用纤维肌痛影响问卷（FIQ）和医疗结局研究 36 项简短健康调查（MOS SF-36）评估 FM 患者的疼痛严重程度和 HRQoL；采用心境谱自评量表（MOODS-SR）评估心境谱症状。
我们发现，FM 患者中存在较高的终生躁狂症状发生率，这些症状与 FIQ 的疼痛视觉模拟量表（“疼痛 VAS”）和 FIQ 总分以及 MOS SF-36 的“躯体疼痛”以及身体和心理成分综合评分相关，在整个样本（n=167）和无双相障碍的 FM 患者（n=160）中均存在这种相关性。
我们的研究结果强调，需要更加关注 FM 患者的躁狂谱系症状和特征，因为它们与疼痛严重程度和更差的 HRQoL 有关。
