Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
Molecules. 2022 Dec 7;27(24):8641. doi: 10.3390/molecules27248641.
Worldwide, the incidence of cancer is on the rise. Current cancer treatments include chemotherapy, radiation therapy, and surgery. Chemotherapy and radiation treatment are typically associated with severe adverse effects and a decline in patients' quality of life. Anti-cancer substances derived from plants and animals need to be evaluated therapeutically as it is cost-effective, have fewer side effects, and can improve cancer patients' quality of life. Recently, bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans. Dressings loaded with BC are beneficial in treating chronic wounds and diabetic foot ulcers. Lactoferrin, a glycoprotein with potent anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial effects, is abundant in BC. The BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravaginally. The biological, genetic, and molecular mechanisms driving BC remain to be determined. Oral BC supplements are generally well-tolerated, but some flatulence and nausea may happen. To evaluate the therapeutic effects, long-term safety, and appropriate dosages of BC drugs, well-designed clinical trials are necessary. The purpose of this article is to emphasize the anti-cancer potential of BC and its constituents.
全球范围内，癌症的发病率呈上升趋势。目前的癌症治疗包括化疗、放疗和手术。化疗和放疗通常会伴随严重的不良反应，并降低患者的生活质量。源于动植物的抗癌物质需要进行治疗评估，因为它们具有成本效益、副作用少，并能提高癌症患者的生活质量。最近，牛初乳（BC）引起了众多研究人员的兴趣，他们研究其在人类中的抗癌潜力。负载 BC 的敷料有益于治疗慢性伤口和糖尿病足溃疡。乳铁蛋白是一种富含 BC 的糖蛋白，具有强大的抗氧化、抗炎、抗癌和抗菌作用。BC 丸经阴道给药时能成功促进低度宫颈上皮内瘤变的消退。BC 发挥作用的生物、遗传和分子机制尚待确定。口服 BC 补充剂通常耐受性良好，但可能会出现一些胀气和恶心。为了评估 BC 药物的治疗效果、长期安全性和合适剂量，需要进行精心设计的临床试验。本文的目的是强调 BC 及其成分的抗癌潜力。
