Department of Laboratory Medical Center, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District, Shenyang 110016, China.
Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Molecules. 2022 Dec 14;27(24):8908. doi: 10.3390/molecules27248908.
Bacterial biofilms are difficult to treat due to their resistance to traditional antibiotics. Although photodynamic therapy (PDT) has made significant progress in biomedical applications, most photosensitizers have poor water solubility and can thus aggregate in hydrophilic environments, leading to the quenching of photosensitizing activity in PDT. Herein, a benzoselenadiazole-containing ligand was designed and synthesized to construct the zirconium (IV)-based benzoselenadiazole-doped metal-organic framework (Se-MOF). Characterizations revealed that Se-MOF is a type of UiO-68 topological framework with regular crystallinity and high porosity. Compared to the MOF without benzoselenadiazole, Se-MOF exhibited a higher O generation efficacy and could effectively kill bacteria under visible-light irradiation. Importantly, in vitro biofilm experiments confirmed that Se-MOF could efficiently inhibit the formation of bacteria biofilms upon visible-light exposure. This study provides a promising strategy for developing MOF-based PDT agents, facilitating their transformation into clinical photodynamic antibacterial applications.
细菌生物膜因其对传统抗生素的耐药性而难以治疗。尽管光动力疗法 (PDT) 在生物医学应用中取得了重大进展，但大多数光敏剂的水溶性较差，因此在亲水环境中会聚集，导致 PDT 中的光敏活性被猝灭。在此，设计并合成了一种含有苯并硒二唑的配体，以构建基于锆 (IV) 的苯并硒二唑掺杂金属-有机骨架 (Se-MOF)。表征结果表明，Se-MOF 是一种具有规则结晶度和高孔隙率的 UiO-68 拓扑骨架。与不含苯并硒二唑的 MOF 相比，Se-MOF 表现出更高的 O 生成效率，并且可以在可见光照射下有效杀死细菌。重要的是，体外生物膜实验证实，Se-MOF 可以在可见光照射下有效抑制细菌生物膜的形成。这项研究为开发基于 MOF 的 PDT 剂提供了一种有前途的策略，有助于将它们转化为临床光动力抗菌应用。
