Ding Yuan, Ding Zheheng, Xu Jin, Li Yueying, Chen Min
Lab of Clinical Chemistry, Danyang Hospital of Tranditional Medicine, Danyang 212300, China.
School of Medicine, Heinrich-Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.
Pharmaceuticals (Basel). 2022 Nov 26;15(12):1469. doi: 10.3390/ph15121469.
Plant-derived natural compounds are widely used as alternative medicine in healthcare throughout the world. Ginkgolic acids, the phenolic compounds isolated from the leaves and seeds of , are among the chemicals that have been explored the most. Ginkgolic acids exhibit cytotoxic activity against a vast number of human cancers in various preclinical models in vitro and in vivo. Additionally, the pharmacological activities of ginkgolic acids are also involved in antidiabetic, anti-bacteria, anti-virus, anti-fibrosis, and reno/neuroprotection. Autophagy as a highly conserved self-cleaning process that plays a crucial role in maintaining cellular and tissue homeostasis and has been proven to serve as a protective mechanism in the pathogenesis of many diseases, including neurodegenerative diseases, cancer, and infectious diseases. In this review, we surveyed the pharmacological activities of the major three forms of ginkgolic acids (C13:0, C15:1, and C17:1) that are linked to autophagic activity and the mechanisms to which these compounds may participate. A growing body of studies in last decade suggests that ginkgolic acids may represent promising chemical compounds in future drug development and an alternative remedy in humans.
植物源天然化合物在全球医疗保健领域被广泛用作替代药物。银杏酸是从银杏叶和种子中分离出的酚类化合物，是研究最多的化学物质之一。在各种体外和体内临床前模型中，银杏酸对大量人类癌症表现出细胞毒性活性。此外，银杏酸的药理活性还涉及抗糖尿病、抗菌、抗病毒、抗纤维化以及肾脏/神经保护作用。自噬是一种高度保守的自我清洁过程，在维持细胞和组织稳态中起着关键作用，并且已被证明在包括神经退行性疾病、癌症和传染病在内的许多疾病的发病机制中作为一种保护机制。在本综述中，我们调查了与自噬活性相关的三种主要形式银杏酸（C13:0、C15:1和C17:1）的药理活性以及这些化合物可能参与的机制。过去十年中越来越多的研究表明，银杏酸可能是未来药物开发中很有前景的化合物以及人类的一种替代疗法。
