腰椎间盘退变的 T1ρ、T2 和 T2* 图谱：一项对比研究。
T1ρ, T2 and T2* mapping of lumbar intervertebral disc degeneration: a comparison study.
机构信息
Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Department of Radiology, Beijing Hospital, National Center of Gerontology, No. 1 Da-Hua Road, Dong Dan, Beijing, 100730, China.
出版信息
BMC Musculoskelet Disord. 2022 Dec 27;23(1):1135. doi: 10.1186/s12891-022-06040-y.
BACKGROUND
Early and accurate assessment of lumbar intervertebral disc degeneration (IVDD) is very important to therapeutic strategy. This study aims to correlate and compare the performances of T1ρ, T2 and T2* mapping for Pfirrmann grades and morphologic changes in the IVDD.
METHODS
This prospective study included 39 subjects with 195 lumbar discs. T1ρ, T2 and T2* mapping were performed, and T1ρ, T2 and T2* values of nucleus pulposus (NP), and anterior and posterior annulus fibrosus were measured. IVDD was assessed with Pfirrmann grading and morphologic changes (normal, bulging, herniation and annular fissure). The performances of T1ρ, T2 and T2* relaxation times were compared for detecting early (Pfirrmann grade II-III) and advanced degeneration (Pfirrmann grade IV-V), as well as for morphologic changes.
RESULTS
T2 relaxation times was strongly corelated with T1ρ and T2* relaxation times. Areas under the curves (AUCs) of T1ρ, T2 and T2* relaxation times of NP were 0.70, 0.87 and 0.80 for early degeneration, and 0.91, 0.95 and 0.82 for advanced degeneration, respectively. AUCs of T1ρ, T2 and T2* relaxation times of NP were 0.78, 0.83 and 0.64 for bulging discs, 0.87, 0.89 and 0.69 for herniated discs, and 0.79, 0.82 and 0.69 for annular tearing, respectively. The AUC of T2 relaxation time was significantly higher than those of T1ρ relaxation times (both P < 0.01) for early IVDD, and the AUCs of T1ρ and T2 relaxation times for assessing advanced degeneration and morphologic changes were similar (P > 0.05) but significantly higher than that of T2*relaxation time (P < 0.01).
CONCLUSIONS
T2 mapping performed better than T1ρ mapping for the detection of early IVDD. T1ρ and T2 mapping performed similarly but better than T2* mapping for advanced degeneration and morphologic changes of IVDD.
背景
早期准确评估腰椎间盘退变（IVDD）对治疗策略非常重要。本研究旨在比较 T1ρ、T2 和 T2* 图谱在 Pfirrmann 分级和 IVDD 形态变化中的相关性和性能。
方法
本前瞻性研究纳入 39 例 195 个腰椎间盘。进行 T1ρ、T2 和 T2* 图谱检查，并测量髓核（NP）、前纤维环和后纤维环的 T1ρ、T2 和 T2* 值。采用 Pfirrmann 分级和形态变化（正常、膨出、突出和环状裂隙）评估 IVDD。比较 T1ρ、T2 和 T2* 弛豫时间在早期（Pfirrmann 分级 II-III）和晚期（Pfirrmann 分级 IV-V）退变以及形态变化中的检测性能。
结果
T2 弛豫时间与 T1ρ 和 T2* 弛豫时间呈强相关。NP 的 T1ρ、T2 和 T2* 弛豫时间的曲线下面积（AUC）分别为早期退变的 0.70、0.87 和 0.80，晚期退变的 0.91、0.95 和 0.82。NP 的 T1ρ、T2 和 T2* 弛豫时间的 AUC 分别为膨出椎间盘的 0.78、0.83 和 0.64，突出椎间盘的 0.87、0.89 和 0.69，环状撕裂的 0.79、0.82 和 0.69。T2 弛豫时间的 AUC 显著高于早期 IVDD 的 T1ρ 弛豫时间（均 P<0.01），而评估晚期退变和形态变化的 T1ρ 和 T2 弛豫时间的 AUC 相似（P>0.05），但显著高于 T2* 弛豫时间（P<0.01）。
结论
T2 图谱在检测早期 IVDD 方面优于 T1ρ 图谱。T1ρ 和 T2 图谱在评估 IVDD 的晚期退变和形态变化方面表现相似，但优于 T2* 图谱。
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