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小鼠基因组中5'端重复序列与L1散在重复家族最大成员之间的关系。

The relationships between the 5' end repeats and the largest members of the L1 interspersed repeated family in the mouse genome.

作者信息

Jubier-Maurin V, Wincker P, Cuny G, Roizès G

机构信息

CNRS (CRBM-LP 8402), INSERM U.249, Institut de Biologie, Montpellier, France.

出版信息

Nucleic Acids Res. 1987 Sep 25;15(18):7395-410. doi: 10.1093/nar/15.18.7395.

DOI:10.1093/nar/15.18.7395
PMID:3658697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC306256/
Abstract

Analysis of a few large L1 elements has revealed two types of tandem repeats at the 5' end: A and F. In this study, the relationships between these repeats and a series of large L1 elements has been analysed. Most of cloned L1 repeats were shown to lack either A or F sequences at their 5' ends. F sequences are found less frequently associated than A sequences to the 5' ends of L1 and an evolutionary comparison shows that the A type was introduced more recently during the evolution of the mouse genome than the F type.

摘要

对一些大型L1元件的分析揭示了其5'端存在两种串联重复序列：A和F。在本研究中，分析了这些重复序列与一系列大型L1元件之间的关系。大多数克隆的L1重复序列在其5'端显示缺乏A或F序列。与A序列相比，F序列在L1的5'端出现的频率较低，进化比较表明，在小鼠基因组进化过程中，A类型比F类型引入的时间更近。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/0e5998ed77a5/nar00262-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/060d83d71b7c/nar00262-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/bea93b1e5dba/nar00262-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/0e5998ed77a5/nar00262-0205-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/060d83d71b7c/nar00262-0200-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/bea93b1e5dba/nar00262-0204-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e9f/306256/0e5998ed77a5/nar00262-0205-a.jpg

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本文引用的文献

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分子生物学。CACA序列——终点还是手段？
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Looking for relationships between the most repeated dispersed DNA sequences in the mouse: small R elements are found associated consistently with long MIF repeats.寻找小鼠中最常见的分散DNA序列之间的关系：发现小R元件始终与长MIF重复序列相关联。
EMBO J. 1984 Feb;3(2):467-72. doi: 10.1002/j.1460-2075.1984.tb01829.x.
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Dispersal process associated with the L1 family of interspersed repetitive DNA sequences.与散布重复DNA序列L1家族相关的扩散过程。
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