Jubier-Maurin V, Wincker P, Cuny G, Roizès G
CNRS (CRBM-LP 8402), INSERM U.249, Institut de Biologie, Montpellier, France.
Nucleic Acids Res. 1987 Sep 25;15(18):7395-410. doi: 10.1093/nar/15.18.7395.
Analysis of a few large L1 elements has revealed two types of tandem repeats at the 5' end: A and F. In this study, the relationships between these repeats and a series of large L1 elements has been analysed. Most of cloned L1 repeats were shown to lack either A or F sequences at their 5' ends. F sequences are found less frequently associated than A sequences to the 5' ends of L1 and an evolutionary comparison shows that the A type was introduced more recently during the evolution of the mouse genome than the F type.
对一些大型L1元件的分析揭示了其5'端存在两种串联重复序列:A和F。在本研究中,分析了这些重复序列与一系列大型L1元件之间的关系。大多数克隆的L1重复序列在其5'端显示缺乏A或F序列。与A序列相比,F序列在L1的5'端出现的频率较低,进化比较表明,在小鼠基因组进化过程中,A类型比F类型引入的时间更近。