Bennett K L, Hastie N D
EMBO J. 1984 Feb;3(2):467-72. doi: 10.1002/j.1460-2075.1984.tb01829.x.
Four highly-repeated dispersed DNA sequence families have been described in the mouse genome. These are the three small elements B1, B2 and R and the large (6 kb) MIF element. Together these comprise approximately 10% of the mouse genome. Possible relationships between these families are pertinent to the genome as a whole. We report here that the B1s, B2s and Rs are all randomly organized in the genome with respect to each other. Surprisingly though, the R and MIF families are found together consistently in a set of random genomic clones and in selected clones. We find Rs often located on one end of the MIF at a consistent site and conclude that a minority of Rs are an integral part of MIF while the majority of Rs are not associated with MIFs. We propose that isolated R elements are truncated forms of MIF. Also we speculate on the mechanism of dispersal of these elements through the mouse genome.
在小鼠基因组中已发现了四个高度重复的分散DNA序列家族。它们是三个小元件B1、B2和R以及大的（6kb）MIF元件。这些元件共同构成了小鼠基因组的约10%。这些家族之间可能的关系与整个基因组相关。我们在此报告，B1、B2和R在基因组中彼此随机排列。然而，令人惊讶的是，在一组随机基因组克隆和选定克隆中，R和MIF家族始终共同出现。我们发现R常常位于MIF一端的一个固定位点，并得出结论，少数R是MIF的组成部分，而大多数R与MIF无关。我们提出，孤立的R元件是MIF的截短形式。此外，我们还推测了这些元件在小鼠基因组中扩散的机制。
