免疫球蛋白轻链基因附近两种不同重复DNA元件的关联。
Association of two different repetitive DNA elements near immunoglobulin light chain genes.
作者信息
Wilson R, Storb U
出版信息
Nucleic Acids Res. 1983 Mar 25;11(6):1803-17. doi: 10.1093/nar/11.6.1803.
Abstract
Sequence studies of repetitive DNA elements approximately 6 kb 3' of the mouse immunoglobulin CK region gene show that the R element located there (Gebhard et al. (1982) J. Mol. Biol. 157, 453-471) is adjacent to a 500 base pair long element which shows 80% homology to the BAM5 element sequenced by Fanning (Nuc. Acids Res. (1982), 10, 5003-5013). Neither the BAM5 element nor the R element itself is surrounded by a direct repeat, but the composite element (BAM5 + R) is surrounded by a 15 base pair direct repeat (with one mismatch). Direct repeats, consisting of target site sequences that surround a repetitive DNA element, are thought to arise during the insertion of the element at that site. It therefore appears that the BAM5 and R elements interacted and inserted as a linked entity. The existence of other BAM5/R composites throughout the mouse lambda chain locus indicates that BAM5-R cooperation is not a rare event.
摘要
对小鼠免疫球蛋白CK区域基因3'端约6 kb处的重复DNA元件进行的序列研究表明，位于该区域的R元件（Gebhard等人，(1982)《分子生物学杂志》157, 453 - 471）与一个500碱基对长的元件相邻，该元件与Fanning测序的BAM5元件（《核酸研究》(1982)，10, 5003 - 5013）具有80%的同源性。BAM5元件和R元件本身都没有被同向重复序列所包围，但复合元件（BAM5 + R）被一个15碱基对的同向重复序列所包围（有一个错配）。由围绕重复DNA元件的靶位点序列组成的同向重复序列，被认为是在该元件插入该位点时产生的。因此，似乎BAM5和R元件作为一个连锁实体相互作用并插入。在整个小鼠λ链基因座中存在其他BAM5/R复合物，这表明BAM5 - R的协同作用并非罕见事件。
相似文献
1
Association of two different repetitive DNA elements near immunoglobulin light chain genes.免疫球蛋白轻链基因附近两种不同重复DNA元件的关联。
Nucleic Acids Res. 1983 Mar 25;11(6):1803-17. doi: 10.1093/nar/11.6.1803.
2
Characterization of four constant region genes of rabbit immunoglobulin-lambda chains.兔免疫球蛋白λ链四个恒定区基因的特征分析
J Immunol. 1986 Jun 1;136(11):4297-302.
3
Molecular cloning of an immunoglobulin kappa constant gene from NZB mouse.从新西兰黑小鼠中克隆免疫球蛋白κ恒定基因
Gene. 1981 Mar;13(2):163-172. doi: 10.1016/0378-1119(81)90005-6.
4
Clustered arrangement of immunoglobulin lambda constant region genes in man.人类免疫球蛋白λ恒定区基因的成簇排列。
Nature. 1981 Dec 10;294(5841):536-40. doi: 10.1038/294536a0.
5
Restricted association of V and J-C gene segments for mouse lambda chains.小鼠λ链V和J-C基因片段的限制性组合
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2484-8. doi: 10.1073/pnas.81.8.2484.
6
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.靠近免疫球蛋白κ恒定区基因编码的五个潜在重组位点的序列。
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3450-4. doi: 10.1073/pnas.76.7.3450.
7
Structural analysis of a rabbit immunoglobulin kappa 2 J-C locus reveals multiple deletions.兔免疫球蛋白κ2 J-C基因座的结构分析揭示了多个缺失。
Nucleic Acids Res. 1983 Dec 20;11(24):8877-90. doi: 10.1093/nar/11.24.8877.
8
Lambda light chain constant and variable gene complements in wild-derived inbred mouse strains.野生来源近交系小鼠品系中的λ轻链恒定区和可变区基因互补情况。
Eur J Immunol. 1985 Jun;15(6):535-40. doi: 10.1002/eji.1830150602.
9
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.克隆的人类和小鼠κ免疫球蛋白恒定区和J区基因在功能片段上保持同源性。
Cell. 1980 Nov;22(1 Pt 1):197-207. doi: 10.1016/0092-8674(80)90168-3.
10
The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes.一段包含小鼠κ免疫球蛋白J区和C区基因的5.5千碱基DNA片段的核苷酸序列。
J Biol Chem. 1981 May 25;256(10):5116-20.
引用本文的文献
1
Immunoglobulin variable gene segment VH81X of the mouse is embedded in L1 transposon sequences.小鼠的免疫球蛋白可变基因片段VH81X嵌入在L1转座子序列中。
Immunogenetics. 1995;41(2-3):172. doi: 10.1007/BF00182336.
2
Looking for relationships between the most repeated dispersed DNA sequences in the mouse: small R elements are found associated consistently with long MIF repeats.寻找小鼠中最常见的分散DNA序列之间的关系：发现小R元件始终与长MIF重复序列相关联。
EMBO J. 1984 Feb;3(2):467-72. doi: 10.1002/j.1460-2075.1984.tb01829.x.
3
Non-Alu family interspersed repeats in human DNA and their transcriptional activity.人类DNA中的非Alu家族散布重复序列及其转录活性。
Nucleic Acids Res. 1984 Mar 26;12(6):2669-90. doi: 10.1093/nar/12.6.2669.
4
A large interspersed repeat found in mouse DNA contains a long open reading frame that evolves as if it encodes a protein.在小鼠DNA中发现的一个大的散布重复序列包含一个长的开放阅读框，其进化方式就好像它编码一种蛋白质。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2308-12. doi: 10.1073/pnas.81.8.2308.
5
The Bam repeats of the mouse genome belong in several superfamilies the longest of which is over 9 kb in size.小鼠基因组的Bam重复序列属于几个超家族，其中最长的超过9千碱基对。
Nucleic Acids Res. 1984 Feb 10;12(3):1593-608. doi: 10.1093/nar/12.3.1593.
6
Homology between the KpnI primate and BamH1 (M1F-1) rodent families of long interspersed repeated sequences.灵长类动物KpnI家族与啮齿动物BamH1（M1F-1）家族长散在重复序列之间的同源性。
Nucleic Acids Res. 1983 Aug 25;11(16):5739-45. doi: 10.1093/nar/11.16.5739.
7
Size and structure of the highly repetitive BAM HI element in mice.小鼠中高度重复的BAM HI元件的大小和结构。
Nucleic Acids Res. 1983 Aug 11;11(15):5073-91. doi: 10.1093/nar/11.15.5073.
8
Localization of the L1Md family of repeated sequences in the mouse albumin-alpha-fetoprotein gene complex.小鼠白蛋白 - 甲胎蛋白基因复合体中重复序列L1Md家族的定位
Nucleic Acids Res. 1984 Aug 24;12(16):6575-86. doi: 10.1093/nar/12.16.6575.
9
The relationships between the 5' end repeats and the largest members of the L1 interspersed repeated family in the mouse genome.小鼠基因组中5'端重复序列与L1散在重复家族最大成员之间的关系。
Nucleic Acids Res. 1987 Sep 25;15(18):7395-410. doi: 10.1093/nar/15.18.7395.
10
Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.编码κ链Ser亚群轻链的单个基因中的结构差异解释了两种小鼠轻链遗传标记的存在。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9134-8. doi: 10.1073/pnas.83.23.9134.
本文引用的文献
1
The nucleotide sequence of the ubiquitous repetitive DNA sequence B1 complementary to the most abundant class of mouse fold-back RNA.与最丰富的一类小鼠回折RNA互补的普遍存在的重复DNA序列B1的核苷酸序列。
Nucleic Acids Res. 1980 Mar 25;8(6):1201-15. doi: 10.1093/nar/8.6.1201.
2
Selfish DNA: the ultimate parasite.自私的DNA：终极寄生虫。
Nature. 1980 Apr 17;284(5757):604-7. doi: 10.1038/284604a0.
3
Repetitive sequences of the sea urchin genome. III. Nucleotide sequences of cloned repeat elements.海胆基因组的重复序列。III. 克隆重复元件的核苷酸序列。
J Mol Biol. 1981 Jun 15;149(1):41-67. doi: 10.1016/0022-2836(81)90259-x.
4
Repetitive sequences of the sea urchin genome. Distribution of members of specific repetitive families.海胆基因组的重复序列。特定重复家族成员的分布。
J Mol Biol. 1981 Jan 5;145(1):5-28. doi: 10.1016/0022-2836(81)90332-6.
5
Repetitive DNA sequences cotranscribed with developmentally regulated Dictyostelium discoideum mRNAs.与发育调控的盘基网柄菌信使核糖核酸共同转录的重复DNA序列。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5386-90. doi: 10.1073/pnas.78.9.5386.
6
A new family of interspersed repetitive DNA sequences in the mouse genome.小鼠基因组中一个新的散布重复DNA序列家族。
J Mol Biol. 1982 May 25;157(3):453-71. doi: 10.1016/0022-2836(82)90471-5.
7
Evolution of mouse immunoglobulin lambda genes.小鼠免疫球蛋白λ基因的进化
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4681-5. doi: 10.1073/pnas.79.15.4681.
8
Low molecular weight RNAs transcribed in vitro by RNA polymerase III from Alu-type dispersed repeats in Chinese hamster DNA are also found in vivo.由RNA聚合酶III体外转录中国仓鼠DNA中Alu型分散重复序列产生的低分子量RNA在体内也能找到。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6130-4. doi: 10.1073/pnas.78.10.6130.
9
Somatic mutation of immunoglobulin light-chain variable-region genes.免疫球蛋白轻链可变区基因的体细胞突变
Cell. 1981 Jul;25(1):47-58. doi: 10.1016/0092-8674(81)90230-0.
10
Characterization of a highly repetitive family of DNA sequences in the mouse.小鼠中一个高度重复的DNA序列家族的特征分析。
Nucleic Acids Res. 1982 Aug 25;10(16):5003-13. doi: 10.1093/nar/10.16.5003.
Zotero 插件