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免疫球蛋白轻链基因附近两种不同重复DNA元件的关联。

Association of two different repetitive DNA elements near immunoglobulin light chain genes.

作者信息

Wilson R, Storb U

出版信息

Nucleic Acids Res. 1983 Mar 25;11(6):1803-17. doi: 10.1093/nar/11.6.1803.

DOI:10.1093/nar/11.6.1803
PMID:6300779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC325837/
Abstract

Sequence studies of repetitive DNA elements approximately 6 kb 3' of the mouse immunoglobulin CK region gene show that the R element located there (Gebhard et al. (1982) J. Mol. Biol. 157, 453-471) is adjacent to a 500 base pair long element which shows 80% homology to the BAM5 element sequenced by Fanning (Nuc. Acids Res. (1982), 10, 5003-5013). Neither the BAM5 element nor the R element itself is surrounded by a direct repeat, but the composite element (BAM5 + R) is surrounded by a 15 base pair direct repeat (with one mismatch). Direct repeats, consisting of target site sequences that surround a repetitive DNA element, are thought to arise during the insertion of the element at that site. It therefore appears that the BAM5 and R elements interacted and inserted as a linked entity. The existence of other BAM5/R composites throughout the mouse lambda chain locus indicates that BAM5-R cooperation is not a rare event.

摘要

对小鼠免疫球蛋白CK区域基因3'端约6 kb处的重复DNA元件进行的序列研究表明，位于该区域的R元件（Gebhard等人，(1982)《分子生物学杂志》157, 453 - 471）与一个500碱基对长的元件相邻，该元件与Fanning测序的BAM5元件（《核酸研究》(1982)，10, 5003 - 5013）具有80%的同源性。BAM5元件和R元件本身都没有被同向重复序列所包围，但复合元件（BAM5 + R）被一个15碱基对的同向重复序列所包围（有一个错配）。由围绕重复DNA元件的靶位点序列组成的同向重复序列，被认为是在该元件插入该位点时产生的。因此，似乎BAM5和R元件作为一个连锁实体相互作用并插入。在整个小鼠λ链基因座中存在其他BAM5/R复合物，这表明BAM5 - R的协同作用并非罕见事件。

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