Meunier-Rotival M, Soriano P, Cuny G, Strauss F, Bernardi G
Proc Natl Acad Sci U S A. 1982 Jan;79(2):355-9. doi: 10.1073/pnas.79.2.355.
We have investigated that organization and the distribution of a family of interspersed DNA repeats in the mouse genome. The repeats are at least 5600 base pairs (bp) in size and contain two contiguous BamHI endonuclease fragments, 4000 and 540 bp in size, the larger of which includes a 1350-bp EcoRI fragment studied by previous authors. The repeats are polymorphic in their restriction maps, and represent the major family of interspersed repeats in the mouse genome. The repeats are present almost exclusively in the two light major components of mouse DNA, and the base composition of their large BamHI fragments matches that of those components. The genomic distribution of the repeats is different from that of structural genes, which are present not only in the two light components but also in the two heavy components of mouse DNA. This distribution indicates that the repeats are not involved, at least in any simple way, in the regulation of gene expression.
我们已经研究了小鼠基因组中一个散布的DNA重复序列家族的组织和分布情况。这些重复序列大小至少为5600个碱基对（bp），包含两个相邻的BamHI内切酶片段，大小分别为4000和540 bp，其中较大的片段包含一个先前作者研究过的1350 bp的EcoRI片段。这些重复序列在其限制酶切图谱中具有多态性，代表了小鼠基因组中散布重复序列的主要家族。这些重复序列几乎只存在于小鼠DNA的两个轻的主要成分中，其大的BamHI片段的碱基组成与那些成分相匹配。这些重复序列的基因组分布与结构基因不同，结构基因不仅存在于小鼠DNA的两个轻成分中，也存在于两个重成分中。这种分布表明，这些重复序列至少没有以任何简单的方式参与基因表达的调控。
