Department of Rehabilitation and Advancement, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Front Public Health. 2022 Dec 15;10:1018866. doi: 10.3389/fpubh.2022.1018866. eCollection 2022.
Low physical activity (LPA) is associated with several major non-communicable diseases (NCDs) and premature mortality. In this study, we aimed to assess the global burden and trends in disease attributable to LPA (DALPA) from 1990 to 2019.
Annual age-standardized disability-adjusted life years (DALYs) and death rates of DALPA [all-cause and five specific causes (ischaemic heart disease, diabetes mellitus, stroke, colon and rectal cancer, and breast cancer)] by sex, age, geographical region and social deprivation index (SDI) score from 1990 to 2019 were available from the Global Burden of Disease (GBD) study 2019. The estimated annual percentage changes (EAPCs) were calculated to quantify the changing trend. A generalized linear model (GLM) was used to explore the relationship between DALYs/death rates of DALPA and sociodemographic factors.
Globally, in 2019, the age-standardized DALYs and death rates of DALPA were 198.42/100,000 (95% UI: 108.16/100,000-360.32/100,000) and 11.10/100,000 (95% UI: 5.66/100,000-19.51/100,000), respectively. There were 15.74 million (8.51-28.61) DALYs and 0.83 million (0.43-1.47) deaths attributable to LPA. Overall, age-standardized DALYs and death rates presented significant downward trends with EAPCs [-0.68% (95% CI: -0.85- -0.50%) for DALYs and -1.00% (95% CI: -1.13- -0.86%) for deaths] from 1990 to 2019. However, age-standardized DALYs and death rates of diabetes mellitus attributable to LPA were substantially increased [EAPC: 0.76% (95% CI: 0.70-0.82%) for DALYs and 0.33% (95% CI: 0.21-0.51%) for deaths]. In the 15-49 age group, DALPA presented significant upward trends [EAPC: 0.74% (95% CI: 0.58-0.91%) for DALYs and 0.31% (95% CI: 0.1-0.51%) for deaths]. The GLM revealed that higher gross domestic product and current health expenditure (% of GDP) were negatively associated with DALYs and death rates of DALPA.
Although global age-standardized DALYs and death rates of DALPA presented downward trends, they still cause a heavy burden worldwide. These rates showed upward trends in the diabetic and 15-49 age groups, which need more attention and health interventions.
低身体活动（LPA）与多种非传染性疾病（NCD）和过早死亡有关。本研究旨在评估 1990 年至 2019 年与 LPA 相关的疾病负担和趋势（DALPA）。
全球疾病负担（GBD）研究 2019 年提供了 1990 年至 2019 年按性别、年龄、地理位置和社会剥夺指数（SDI）得分划分的所有原因和五种特定原因（缺血性心脏病、糖尿病、中风、结肠和直肠癌以及乳腺癌）的 DALPA 年龄标准化残疾调整生命年（DALYs）和死亡率。计算估计年百分比变化（EAPC）以量化变化趋势。使用广义线性模型（GLM）探索 DALPA 的 DALYs/死亡率与社会人口因素之间的关系。
2019 年，全球 LPA 的年龄标准化 DALYs 和死亡率分别为 198.42/100,000（95%置信区间：108.16/100,000-360.32/100,000）和 11.10/100,000（95%置信区间：5.66/100,000-19.51/100,000）。有 1574 万人（8.51-28.61）患有 DALYs 和 83 万人（0.43-1.47）归因于 LPA 的死亡。总体而言，1990 年至 2019 年，年龄标准化的 DALYs 和死亡率呈显著下降趋势，EAPC 分别为[-0.68%（95%置信区间：-0.85%-0.50%）和-1.00%（95%置信区间：-1.13%-0.86%）]。然而，归因于 LPA 的糖尿病的年龄标准化 DALYs 和死亡率显著增加[EAPC：0.76%（95%置信区间：0.70%-0.82%）和 0.33%（95%置信区间：0.21%-0.51%）]。在 15-49 岁年龄组中，DALPA 呈现出显著的上升趋势[EAPC：0.74%（95%置信区间：0.58%-0.91%）和 0.31%（95%置信区间：0.1%-0.51%）]。GLM 显示，更高的国内生产总值和当前卫生支出（占 GDP 的百分比）与 DALPA 的 DALYs 和死亡率呈负相关。
尽管全球年龄标准化的 DALYs 和 DALPA 死亡率呈下降趋势，但它们仍在全球范围内造成沉重负担。这些比率在糖尿病和 15-49 岁年龄组中呈上升趋势，需要更多关注和健康干预。
