Weber R W, Petty W E, Nelson H S
J Allergy Clin Immunol. 1979 Feb;63(2):116-21. doi: 10.1016/0091-6749(79)90201-x.
Sixteen patients with bronchial asthma participated in three studies of inhaled terbutaline. Onset of action, duration, and peak effects were compared for a dose of 0.5 mg given in one, two, or four inhalations at 1 min intervals from a freon-propelled, metered-dose aerosol. There was no significant difference in the response between the schedules. Dose-response curves were compared for terbutaline from a metered-dose aerosol, and pressure nebulized with and without intermittent positive pressure breathing (IPPB). There was no difference between the response with IPPB and simple nebulization. Improvement continued to the total dose administered of 9.0 mg. For a given bronchial response, six to eight times as much terbutaline was required by pressure nebulization as from the metered-dose aerosol.
16例支气管哮喘患者参与了三项吸入特布他林的研究。比较了使用氟利昂驱动的定量气雾剂，以1分钟的间隔分别进行1次、2次或4次吸入给予0.5毫克剂量时的起效时间、持续时间和峰值效应。不同给药方案之间的反应没有显著差异。比较了定量气雾剂、有无间歇正压通气（IPPB）的压力雾化特布他林的剂量-反应曲线。IPPB与单纯雾化之间的反应没有差异。持续给予总量为9.0毫克时症状持续改善。对于给定的支气管反应，压力雾化所需的特布他林是定量气雾剂的6至8倍。
