Othmer H G, Aldridge J A
J Math Biol. 1978 Mar 3;5(2):169-200. doi: 10.1007/BF00275897.
Density-dependent regulation of cell growth in tissue culture is a well-known phenomenon but the mechanism of regulation remains obscure. Here we explore the effects of cell density and metabolite flux on the collective dynamics of a cell population. The intracellular dynamics are modelled by positive feedback kinetic mechanisms of the kind known to apply to yeast cells. Several experimental observations related to glycolytic oscillations are predicted and it is suggested that the general conclusions may be applicable in a broader context.
组织培养中细胞生长的密度依赖性调节是一个众所周知的现象，但调节机制仍不清楚。在这里，我们探讨细胞密度和代谢物通量对细胞群体集体动态的影响。细胞内动态由已知适用于酵母细胞的正反馈动力学机制建模。预测了一些与糖酵解振荡相关的实验观察结果，并表明一般结论可能适用于更广泛的背景。
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