Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Mol Cell. 2023 Jan 5;83(1):6-8. doi: 10.1016/j.molcel.2022.12.011.
The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation.
雷帕霉素复合物 1 （mTORC1）的机械靶点通过 GATOR1/2-Rag 轴感知细胞内亮氨酸水平。Jiang 等人表明 GATOR2 亚基的环结构域维持复合物的完整性，并促进 GATOR1 的泛素化和抑制，从而导致 mTORC1 的激活。
