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可穿戴设备在帕金森病诊断和治疗中的应用。

The use of wearables for the diagnosis and treatment of Parkinson's disease.

机构信息

Department of Neurology, University Hospital Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.

出版信息

J Neural Transm (Vienna). 2023 Jun;130(6):783-791. doi: 10.1007/s00702-022-02575-5. Epub 2023 Jan 7.

DOI:10.1007/s00702-022-02575-5
PMID:36609737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10199831/
Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder, with increasing numbers of affected patients. Many patients lack adequate care due to insufficient specialist neurologists/geriatricians, and older patients experience difficulties traveling far distances to reach their treating physicians. A new option for these obstacles would be telemedicine and wearables. During the last decade, the development of wearable sensors has allowed for the continuous monitoring of bradykinesia and dyskinesia. Meanwhile, other systems can also detect tremors, freezing of gait, and gait problems. The most recently developed systems cover both sides of the body and include smartphone apps where the patients have to register their medication intake and well-being. In turn, the physicians receive advice on changing the patient's medication and recommendations for additional supportive therapies such as physiotherapy. The use of smartphone apps may also be adapted to detect PD symptoms such as bradykinesia, tremor, voice abnormalities, or changes in facial expression. Such tools can be used for the general population to detect PD early or for known PD patients to detect deterioration. It is noteworthy that most PD patients can use these digital tools. In modern times, wearable sensors and telemedicine open a new window of opportunity for patients with PD that are easy to use and accessible to most of the population.

摘要

帕金森病(PD)是第二常见的神经退行性疾病,患病人数不断增加。由于缺乏足够的专科神经科医生/老年病医生,许多患者得不到充分的护理,而且老年患者由于路途遥远难以前往治疗医生处就诊。远程医疗和可穿戴设备为这些障碍提供了新的选择。在过去十年中,可穿戴传感器的发展使得对运动迟缓症和运动障碍的连续监测成为可能。同时,其他系统还可以检测震颤、步态冻结和步态问题。最近开发的系统覆盖身体的两侧,并包括智能手机应用程序,患者必须在其中登记他们的药物摄入和健康状况。反过来,医生会收到有关更改患者药物的建议以及对物理治疗等额外支持性治疗的建议。智能手机应用程序的使用也可以适应于检测帕金森病的症状,如运动迟缓、震颤、语音异常或面部表情变化。这些工具可用于普通人群早期发现帕金森病,或用于已知帕金森病患者发现病情恶化。值得注意的是,大多数帕金森病患者都可以使用这些数字工具。在现代,可穿戴传感器和远程医疗为帕金森病患者提供了一个新的机会窗口,这些工具易于使用,大多数人都可以接触到。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b033/10199831/e0b6d630d6dc/702_2022_2575_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b033/10199831/c2e0ed3c596a/702_2022_2575_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b033/10199831/e0b6d630d6dc/702_2022_2575_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b033/10199831/c2e0ed3c596a/702_2022_2575_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b033/10199831/e0b6d630d6dc/702_2022_2575_Fig2_HTML.jpg

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Sensor Measurements Can Characterize Fluctuations and Wearing Off in Parkinson's Disease and Guide Therapy to Improve Motor, Non-motor and Quality of Life Scores.传感器测量可表征帕金森病的波动和药效减退情况,并指导治疗以提高运动、非运动及生活质量评分。
Front Aging Neurosci. 2022 Mar 23;14:852992. doi: 10.3389/fnagi.2022.852992. eCollection 2022.
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Feasibility of a Multimodal Telemedical Intervention for Patients with Parkinson's Disease-A Pilot Study.
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Sensors (Basel). 2025 Jun 30;25(13):4071. doi: 10.3390/s25134071.
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The future of Parkinson's care: a need to expand access.帕金森病护理的未来:扩大可及性的必要性。
Front Neurol. 2025 Jun 19;16:1622283. doi: 10.3389/fneur.2025.1622283. eCollection 2025.
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