Maciel Gabriel Bassan Marinho, Maciel Roberto Marinho, Danesi Cristiane Cademartori
Postgraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Department of Pathology, Federal University of Santa Maria, Av. Roraima, 1000, Santa Maria, 97015-900, RS, Brazil.
Mol Biol Rep. 2023 Mar;50(3):2857-2863. doi: 10.1007/s11033-022-08190-7. Epub 2023 Jan 6.
This work compiles the characteristics of bone cells involved in the physiological bone remodeling.
A narrative review of the literature was performed.
Remodeling is a different process from modeling. Remodeling allows old or damaged bone tissue to be renewed, ensuring the maintenance of bone fracture resistance, as well as maintaining calcium and phosphorus homeostasis. We present the role of osteoclasts, a multinucleated cell with hematopoietic origin responsible for resorbing bone. The formation of osteoclasts depends on the cytokines macrophage colony stimulating factor (M-CSF) and receptor activator of NF-kB ligand (RANKL) and can be blocked by osteoprotegerin. Furthermore, this review highlights the features of osteoblasts, polarized cubic cells of mesenchymal origin that deposit bone and also covers osteocytes and bone lining cells. This review presents the five fundamental phases of bone remodeling and addresses aspects of its regulation through hormones and growth factors.
Knowledge of the current concepts of physiological bone remodeling is necessary for the study of the different pathologies that affect the bone tissue and thus helps in the search for new therapies.
本研究汇编了参与生理性骨重塑的骨细胞的特征。
对文献进行叙述性综述。
重塑是一个与建模不同的过程。重塑使陈旧或受损的骨组织得以更新，确保维持骨的抗骨折能力，并维持钙和磷的稳态。我们阐述了破骨细胞的作用，破骨细胞是一种起源于造血系统的多核细胞，负责吸收骨组织。破骨细胞的形成依赖于细胞因子巨噬细胞集落刺激因子（M-CSF）和核因子κB受体活化因子配体（RANKL），并且可被骨保护素阻断。此外，本综述强调了成骨细胞的特征，成骨细胞是起源于间充质的极化立方体细胞，负责沉积骨组织，还涵盖了骨细胞和骨衬细胞。本综述介绍了骨重塑的五个基本阶段，并探讨了通过激素和生长因子对其进行调节的相关方面。
了解生理性骨重塑的当前概念对于研究影响骨组织的不同病理学是必要的，从而有助于寻找新的治疗方法。
