LeGrady D, Dyer A R, Shekelle R B, Stamler J, Liu K, Paul O, Lepper M, Shryock A M
Dept. of Community Health and Preventive Medicine, Northwestern U. Medical School, Chicago, IL 60611.
Am J Epidemiol. 1987 Nov;126(5):803-12. doi: 10.1093/oxfordjournals.aje.a114717.
The relations between coffee consumption and 19-year mortality from all causes, coronary heart disease, and non-coronary causes were assessed in 1,910 white males aged 40-56 years in 1957-1958 from the Chicago Western Electric Company Study. Mortality rates, adjusted for age, serum cholesterol, diastolic blood pressure, and smoking status, were compared for those consuming 0-1, 2-3, 4-5, and 6+ cups of coffee per day; coffee intake, measured at the first anniversary examination, included both caffeinated and decaffeinated intake. Mortality from all causes was greatest in the highest and lowest intake groups. The increased mortality in the 6+ cups per day group was due to coronary heart disease, while the increased mortality in the lowest intake group was due to noncoronary causes. The adjusted relative risk of coronary heart disease death for those drinking 6+ cups of coffee per day compared with those drinking less was 1.71 (95 per cent confidence limits 1.27, 2.30). This increased risk of coronary heart disease death was present in both smokers and nonsmokers, with adjusted relative risks of 1.62 and 2.21, respectively (95 per cent confidence limits 1.17, 2.24 and 1.06, 4.62). The increased mortality from non-coronary causes in the lowest intake group was due primarily to increased mortality from cancer and cardiovascular diseases other than coronary heart disease. The results of this study support the hypothesis that those who drink 6+ cups of coffee per day may be at an increased risk of death from coronary heart disease.
在1957 - 1958年，从芝加哥西部电气公司研究中选取了1910名年龄在40 - 56岁的白人男性，评估咖啡摄入量与全因死亡率、冠心病死亡率和非冠心病原因死亡率之间的关系。对每日饮用0 - 1杯、2 - 3杯、4 - 5杯和6杯以上咖啡的人群，比较其经年龄、血清胆固醇、舒张压和吸烟状况调整后的死亡率；在首次周年检查时测量的咖啡摄入量，包括含咖啡因和不含咖啡因的摄入量。全因死亡率在摄入量最高和最低的组中最高。每日饮用6杯以上咖啡组死亡率增加是由于冠心病，而最低摄入量组死亡率增加是由于非冠心病原因。与饮用较少咖啡的人群相比，每日饮用6杯以上咖啡人群冠心病死亡的调整后相对风险为1.71（95%置信区间1.27, 2.30）。这种冠心病死亡风险增加在吸烟者和非吸烟者中均存在，调整后相对风险分别为1.62和2.21（95%置信区间1.17, 2.24和1.06, 4.62）。最低摄入量组非冠心病原因导致的死亡率增加主要是由于癌症和除冠心病外的心血管疾病死亡率增加。本研究结果支持以下假设：每日饮用6杯以上咖啡的人群可能死于冠心病的风险增加。
