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两项芝加哥流行病学研究中的饮酒、心血管危险因素与死亡率

Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies.

作者信息

Dyer A R, Stamler J, Paul O, Berkson D M, Lepper M H, McKean H, Shekelle R B, Lindberg H A, Garside D

出版信息

Circulation. 1977 Dec;56(6):1067-74. doi: 10.1161/01.cir.56.6.1067.

Abstract

Multivariate analysis of the association at baseline between problem drinking and cardiovascular risk factors among 1,233 white male employees of the Chicago Peoples Gas Company age 40-59 showed the 38 problem drinkers with significantly higher blood pressures and cigarette consumption and significantly lower relative weights than the others. Similar analysis among 1,899 white male employees of the Hawthorne Works of the Western Electric Company in Chicago age 40-55 showed the 117 men consuming 5 or more drinks per day with significantly higher blood pressures and cigarette use than the others. No significant differences were recorded between heavy drinkers and the others in serum cholesterol level. The gas company problem drinkers had significantly higher 15-year mortality rates from all causes, cardiovascular diseases, coronary heart disease, and sudden death. These differences could not be entirely explained by their blood pressure, smoking, and relative weight status. The Western Electric heavy drinkers had increased 10-year mortality rates both for all causes and noncardiovascular causes.

摘要

对芝加哥人民煤气公司1233名年龄在40至59岁之间的白人男性员工进行的多变量分析显示,38名问题饮酒者的血压和吸烟量显著高于其他人,相对体重显著低于其他人。对芝加哥西部电气公司霍桑工厂1899名年龄在40至55岁之间的白人男性员工进行的类似分析显示,117名每天饮酒5杯或更多的男性的血压和吸烟量显著高于其他人。重度饮酒者与其他人的血清胆固醇水平没有显著差异。煤气公司的问题饮酒者因各种原因、心血管疾病、冠心病和猝死导致的15年死亡率显著更高。这些差异不能完全由他们的血压、吸烟和相对体重状况来解释。西部电气公司的重度饮酒者因各种原因和非心血管原因导致的10年死亡率都有所上升。

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