Chen Qingxue, Yin Qianlong, Xie Qinggang, Liu Sibo, Guo Zengwang, Li Bailiang
Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China; Food College, Northeast Agricultural University, Harbin 150030, China; National Center of Technology Innovation for Dairy, Hohhot 150030, China.
Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China; Food College, Northeast Agricultural University, Harbin 150030, China.
Food Chem. 2023 Jun 1;410:135413. doi: 10.1016/j.foodchem.2023.135413. Epub 2023 Jan 5.
The gut microbiota plays an evolutionarily conserved role in host metabolism, which is influenced by diet. Here, we investigated differences in shaping the gut microbiota and regulating metabolism in cow milk-based infant formula, goat milk-based infant formula, and mix milk-based infant formula compared with pasteurized human milk. 16S rRNA results showed that goat milk-based infant formula selectively increased the relative abundance of Blautia, Roseburia, Alistites and Muribaculum in the gut compared to other infant formulas. Metabolomics identification indicated that goat milk-based infant formula mainly emphasized bile acid biosynthesis, arachidonic acid metabolism and steroid biosynthesis metabolic pathways. Metabolites associated with these metabolic pathways were positively associated with increased microorganisms in goat milk-based infant formula, particularly Alistipes. Furthermore, we found a deficiency of Akkermansia abundance in three infant formula-fed compared to pasteurizedhuman milk-fed. This study presents new insights into the improvement and application of goat milk-based infant formulas in terms of intestinal microecology.
肠道微生物群在宿主代谢中发挥着进化上保守的作用，而宿主代谢会受到饮食的影响。在此，我们研究了与巴氏杀菌母乳相比，以牛奶为基础的婴儿配方奶粉、以羊奶为基础的婴儿配方奶粉和混合奶为基础的婴儿配方奶粉在塑造肠道微生物群和调节代谢方面的差异。16S rRNA结果显示，与其他婴儿配方奶粉相比，以羊奶为基础的婴儿配方奶粉能选择性地增加肠道中布劳特氏菌属、罗斯氏菌属、阿里斯氏菌属和穆里杆菌属的相对丰度。代谢组学鉴定表明，以羊奶为基础的婴儿配方奶粉主要强调胆汁酸生物合成、花生四烯酸代谢和类固醇生物合成代谢途径。与这些代谢途径相关的代谢物与以羊奶为基础的婴儿配方奶粉中微生物的增加呈正相关，尤其是艾氏菌属。此外，我们发现与巴氏杀菌母乳喂养的婴儿相比，三种婴儿配方奶粉喂养的婴儿中阿克曼氏菌丰度不足。这项研究为以羊奶为基础的婴儿配方奶粉在肠道微生态方面的改进和应用提供了新的见解。
